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The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models.
Lemos C, Schulze VK, Baumgart SJ, Nevedomskaya E, Heinrich T, Lefranc J, Bader B, Christ CD, Briem H, Kuhnke LP, Holton SJ, Bömer U, Lienau P, von Nussbaum F, Nising CF, Bauser M, Hägebarth A, Mumberg D, Haendler B. Lemos C, et al. Among authors: heinrich t. Cell Oncol (Dordr). 2021 Jun;44(3):581-594. doi: 10.1007/s13402-020-00584-8. Epub 2021 Jan 25. Cell Oncol (Dordr). 2021. PMID: 33492659
Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor.
Lefranc J, Schulze VK, Hillig RC, Briem H, Prinz F, Mengel A, Heinrich T, Balint J, Rengachari S, Irlbacher H, Stöckigt D, Bömer U, Bader B, Gradl SN, Nising CF, von Nussbaum F, Mumberg D, Panne D, Wengner AM. Lefranc J, et al. Among authors: heinrich t. J Med Chem. 2020 Jan 23;63(2):601-612. doi: 10.1021/acs.jmedchem.9b01460. Epub 2020 Jan 10. J Med Chem. 2020. PMID: 31859507
Gene expression levels of matrix metalloproteinases in human atherosclerotic plaques and evaluation of radiolabeled inhibitors as imaging agents for plaque vulnerability.
Müller A, Krämer SD, Meletta R, Beck K, Selivanova SV, Rancic Z, Kaufmann PA, Vos B, Meding J, Stellfeld T, Heinrich TK, Bauser M, Hütter J, Dinkelborg LM, Schibli R, Ametamey SM. Müller A, et al. Among authors: heinrich tk. Nucl Med Biol. 2014 Aug;41(7):562-9. doi: 10.1016/j.nucmedbio.2014.04.085. Epub 2014 Apr 21. Nucl Med Biol. 2014. PMID: 24853402
Design, synthesis, and initial evaluation of a high affinity positron emission tomography probe for imaging matrix metalloproteinases 2 and 9.
Selivanova SV, Stellfeld T, Heinrich TK, Müller A, Krämer SD, Schubiger PA, Schibli R, Ametamey SM, Vos B, Meding J, Bauser M, Hütter J, Dinkelborg LM. Selivanova SV, et al. Among authors: heinrich tk. J Med Chem. 2013 Jun 27;56(12):4912-20. doi: 10.1021/jm400156p. Epub 2013 Jun 7. J Med Chem. 2013. PMID: 23688254
Preclinical characterization of a novel class of 18F-labeled PET tracers for amyloid-β.
Brockschnieder D, Schmitt-Willich H, Heinrich T, Varrone A, Gulyás B, Toth M, Andersson J, Boemer U, Krause S, Friebe M, Dinkelborg L, Halldin C, Dyrks T. Brockschnieder D, et al. Among authors: heinrich t. J Nucl Med. 2012 Nov;53(11):1794-801. doi: 10.2967/jnumed.112.104810. Epub 2012 Sep 24. J Nucl Med. 2012. PMID: 23008501 Free article.
18-kDa translocator protein ligand 18F-FEMPA: Biodistribution and uptake into atherosclerotic plaques in mice.
Hellberg S, Silvola JMU, Kiugel M, Liljenbäck H, Savisto N, Li XG, Thiele A, Lehmann L, Heinrich T, Vollmer S, Hakovirta H, Laine VJO, Ylä-Herttuala S, Knuuti J, Roivainen A, Saraste A. Hellberg S, et al. Among authors: heinrich t. J Nucl Cardiol. 2017 Jun;24(3):862-871. doi: 10.1007/s12350-016-0527-y. Epub 2016 May 25. J Nucl Cardiol. 2017. PMID: 27225517 Free article.
211 results