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Fragment-Based Discovery of Novel Allosteric MEK1 Binders.
Di Fruscia P, Edfeldt F, Shamovsky I, Collie GW, Aagaard A, Barlind L, Börjesson U, Hansson EL, Lewis RJ, Nilsson MK, Öster L, Pemberton J, Ripa L, Storer RI, Käck H. Di Fruscia P, et al. Among authors: shamovsky i. ACS Med Chem Lett. 2021 Jan 27;12(2):302-308. doi: 10.1021/acsmedchemlett.0c00563. eCollection 2021 Feb 11. ACS Med Chem Lett. 2021. PMID: 33603979 Free PMC article.
Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites.
Shamovsky I, de Graaf C, Alderin L, Bengtsson M, Bladh H, Börjesson L, Connolly S, Dyke HJ, van den Heuvel M, Johansson H, Josefsson BG, Kristoffersson A, Linnanen T, Lisius A, Männikkö R, Nordén B, Price S, Ripa L, Rognan D, Rosendahl A, Skrinjar M, Urbahns K. Shamovsky I, et al. J Med Chem. 2009 Dec 10;52(23):7706-23. doi: 10.1021/jm900713y. J Med Chem. 2009. PMID: 19954248
Identification and Optimization of Pyrrolidine Derivatives as Highly Potent Ghrelin Receptor Full Agonists.
Cooper M, Llinas A, Hansen P, Caffrey M, Ray A, Sjödin S, Shamovsky I, Wada H, Jellesmark Jensen T, Sivars U, Hultin L, Andersson U, Lundqvist S, Gedda K, Jinton L, Krutrök N, Lewis R, Jansson P, Gardelli C. Cooper M, et al. Among authors: shamovsky i. J Med Chem. 2020 Sep 10;63(17):9705-9730. doi: 10.1021/acs.jmedchem.0c00828. Epub 2020 Aug 27. J Med Chem. 2020. PMID: 32787075
Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism.
Ripa L, Sandmark J, Hughes G, Shamovsky I, Gunnarsson A, Johansson J, Llinas A, Collins M, Jung B, Novén A, Pemberton N, Mogemark M, Xiong Y, Li Q, Tångefjord S, Ek M, Åstrand A. Ripa L, et al. Among authors: shamovsky i. J Med Chem. 2023 Oct 26;66(20):14188-14207. doi: 10.1021/acs.jmedchem.3c01269. Epub 2023 Oct 5. J Med Chem. 2023. PMID: 37797307
48 results