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BET bromodomain inhibitors PFI-1 and JQ1 are identified in an epigenetic compound screen to enhance C9ORF72 gene expression and shown to ameliorate C9ORF72-associated pathological and behavioral abnormalities in a C9ALS/FTD model.
Quezada E, Cappelli C, Diaz I, Jury N, Wightman N, Brown RH Jr, Montecino M, van Zundert B. Quezada E, et al. Among authors: cappelli c. Clin Epigenetics. 2021 Mar 16;13(1):56. doi: 10.1186/s13148-021-01039-z. Clin Epigenetics. 2021. PMID: 33726839 Free PMC article.
Ski Is Required for Tri-Methylation of H3K9 in Major Satellite and for Repression of Pericentromeric Genes: Mmp3, Mmp10 and Mmp13, in Mouse Fibroblasts.
Cappelli C, Sepulveda H, Rivas S, Pola V, Urzúa U, Donoso G, Sagredo E, Carrero D, Casanova-Ortiz E, Sagredo A, González M, Manterola M, Nardocci G, Armisén R, Montecino M, Marcelain K. Cappelli C, et al. J Mol Biol. 2020 May 1;432(10):3222-3238. doi: 10.1016/j.jmb.2020.03.013. Epub 2020 Mar 19. J Mol Biol. 2020. PMID: 32198114
The TGF-β profibrotic cascade targets ecto-5'-nucleotidase gene in proximal tubule epithelial cells and is a traceable marker of progressive diabetic kidney disease.
Cappelli C, Tellez A, Jara C, Alarcón S, Torres A, Mendoza P, Podestá L, Flores C, Quezada C, Oyarzún C, San Martín R. Cappelli C, et al. Biochim Biophys Acta Mol Basis Dis. 2020 Jul 1;1866(7):165796. doi: 10.1016/j.bbadis.2020.165796. Epub 2020 Apr 11. Biochim Biophys Acta Mol Basis Dis. 2020. PMID: 32289379 Free article.
Correction to: Microencapsulation of cellular aggregates composed of differentiated insulin and glucagon-producing cells from human mesenchymal stem cells derived from adipose tissue.
Jara C, Oyarzun-Ampuero F, Carrión F, González-Echeverría E, Cappelli C, Caviedes P. Jara C, et al. Among authors: cappelli c. Diabetol Metab Syndr. 2020 Aug 19;12:74. doi: 10.1186/s13098-020-00581-9. eCollection 2020. Diabetol Metab Syndr. 2020. PMID: 32843901 Free PMC article.
392 results