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Verifying the role of 3-hydroxy of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[(4'-pyridyl) carboxamido]morphinan derivatives via their binding affinity and selectivity profiles on opioid receptors.
Huang B, Gunta R, Wang H, Li M, Cao D, Mendez RE, Gillespie JC, Chen C, Huang LM, Liu-Chen LY, Selley DE, Zhang Y. Huang B, et al. Among authors: mendez re. Bioorg Chem. 2021 Apr;109:104702. doi: 10.1016/j.bioorg.2021.104702. Epub 2021 Feb 9. Bioorg Chem. 2021. PMID: 33631465 Free PMC article.
Design, Synthesis, and Biological Evaluation of NAP Isosteres: A Switch from Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists.
Pagare PP, Li M, Zheng Y, Kulkarni AS, Obeng S, Huang B, Ruiz C, Gillespie JC, Mendez RE, Stevens DL, Poklis JL, Halquist MS, Dewey WL, Selley DE, Zhang Y. Pagare PP, et al. Among authors: mendez re. J Med Chem. 2022 Mar 24;65(6):5095-5112. doi: 10.1021/acs.jmedchem.2c00087. Epub 2022 Mar 7. J Med Chem. 2022. PMID: 35255685 Free PMC article.
Characterization of a Potential KOR/DOR Dual Agonist with No Apparent Abuse Liability via a Complementary Structure-Activity Relationship Study on Nalfurafine Analogues.
Li M, Stevens DL, Arriaga M, Townsend EA, Mendez RE, Blajkevch NA, Selley DE, Banks ML, Negus SS, Dewey WL, Zhang Y. Li M, et al. Among authors: mendez re. ACS Chem Neurosci. 2022 Dec 21;13(24):3608-3628. doi: 10.1021/acschemneuro.2c00526. Epub 2022 Nov 30. ACS Chem Neurosci. 2022. PMID: 36449691 Free PMC article.
Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease.
Bhatt DL, Szarek M, Pitt B, Cannon CP, Leiter LA, McGuire DK, Lewis JB, Riddle MC, Inzucchi SE, Kosiborod MN, Cherney DZI, Dwyer JP, Scirica BM, Bailey CJ, Díaz R, Ray KK, Udell JA, Lopes RD, Lapuerta P, Steg PG; SCORED Investigators. Bhatt DL, et al. N Engl J Med. 2021 Jan 14;384(2):129-139. doi: 10.1056/NEJMoa2030186. Epub 2020 Nov 16. N Engl J Med. 2021. PMID: 33200891 Clinical Trial.
25 results