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Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers.
Mol Cancer Ther. 2021 Jun;20(6):999-1008. doi: 10.1158/1535-7163.MCT-21-0077. Epub 2021 Mar 30.
Mol Cancer Ther. 2021.
PMID: 33785651
Desymmetrization of pibrentasvir for efficient prodrug synthesis.
Voight EA, Greszler SN, Hartung J, Ji J, Klix RC, Randolph JT, Shelat BH, Waters JE, DeGoey DA.
Voight EA, et al. Among authors: klix rc.
Chem Sci. 2021 Jun 29;12(29):10076-10082. doi: 10.1039/d1sc02396a. eCollection 2021 Jul 28.
Chem Sci. 2021.
PMID: 34349971
Free PMC article.
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Scalable Asymmetric Syntheses of Foslevodopa and Foscarbidopa Drug Substances for the Treatment of Parkinson's Disease.
Huters AD, Stambuli J, Klix RC, Matulenko MA, Chan VS, Simanis J, Hill DR, Reddy RE, Towne TB, Bellettini JR, Kotecki BJ, Cardinal-David B, Ji J, Voight EA, Shou M, Balaraman S, Ashok A, Ghosh S.
Huters AD, et al. Among authors: klix rc.
J Org Chem. 2022 Feb 18;87(4):1986-1995. doi: 10.1021/acs.joc.1c00905. Epub 2021 Jul 19.
J Org Chem. 2022.
PMID: 34280307
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Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1.
Yeh VS, Beno DW, Brodjian S, Brune ME, Cullen SC, Dayton BD, Dhaon MK, Falls HD, Gao J, Grihalde N, Hajduk P, Hansen TM, Judd AS, King AJ, Klix RC, Larson KJ, Lau YY, Marsh KC, Mittelstadt SW, Plata D, Rozema MJ, Segreti JA, Stoner EJ, Voorbach MJ, Wang X, Xin X, Zhao G, Collins CA, Cox BF, Reilly RM, Kym PR, Souers AJ.
Yeh VS, et al. Among authors: klix rc.
J Med Chem. 2012 Feb 23;55(4):1751-7. doi: 10.1021/jm201524g. Epub 2012 Feb 10.
J Med Chem. 2012.
PMID: 22263872
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