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Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease.
Rossi M, Freschi M, de Camargo Nascente L, Salerno A, de Melo Viana Teixeira S, Nachon F, Chantegreil F, Soukup O, Prchal L, Malaguti M, Bergamini C, Bartolini M, Angeloni C, Hrelia S, Soares Romeiro LA, Bolognesi ML. Rossi M, et al. Among authors: prchal l. J Med Chem. 2021 Apr 22;64(8):4972-4990. doi: 10.1021/acs.jmedchem.1c00048. Epub 2021 Apr 8. J Med Chem. 2021. PMID: 33829779 Free PMC article.
Donepezil Derivatives Targeting Amyloid-β Cascade in Alzheimer's Disease.
Mezeiova E, Chalupova K, Nepovimova E, Gorecki L, Prchal L, Malinak D, Kuca K, Soukup O, Korabecny J. Mezeiova E, et al. Among authors: prchal l. Curr Alzheimer Res. 2019;16(9):772-800. doi: 10.2174/1567205016666190228122956. Curr Alzheimer Res. 2019. PMID: 30819078 Review.
A novel class of small molecule inhibitors with radioprotective properties.
Marek J, Tichy A, Havelek R, Seifrtova M, Filipova A, Andrejsova L, Kucera T, Prchal L, Muckova L, Rezacova M, Sinkorova Z, Pejchal J. Marek J, et al. Among authors: prchal l. Eur J Med Chem. 2020 Feb 1;187:111606. doi: 10.1016/j.ejmech.2019.111606. Epub 2020 Jan 1. Eur J Med Chem. 2020. PMID: 31901334
Wide-Antimicrobial Spectrum of Picolinium Salts.
Salajkova S, Benkova M, Marek J, Sleha R, Prchal L, Malinak D, Dolezal R, Sepčić K, Gunde-Cimerman N, Kuca K, Soukup O. Salajkova S, et al. Among authors: prchal l. Molecules. 2020 May 11;25(9):2254. doi: 10.3390/molecules25092254. Molecules. 2020. PMID: 32403238 Free PMC article.
The wide-spectrum antimicrobial effect of novel N-alkyl monoquaternary ammonium salts and their mixtures; the QSAR study against bacteria.
Soukup O, Benkova M, Dolezal R, Sleha R, Malinak D, Salajkova S, Markova A, Hympanova M, Prchal L, Ryskova L, Hobzova L, Sepčić K, Gunde-Cimerman N, Korabecny J, Jun D, Bostikova V, Bostik P, Marek J. Soukup O, et al. Among authors: prchal l. Eur J Med Chem. 2020 Nov 15;206:112584. doi: 10.1016/j.ejmech.2020.112584. Epub 2020 Jul 19. Eur J Med Chem. 2020. PMID: 32853858
Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists.
Konecny J, Misiachna A, Hrabinova M, Pulkrabkova L, Benkova M, Prchal L, Kucera T, Kobrlova T, Finger V, Kolcheva M, Kortus S, Jun D, Valko M, Horak M, Soukup O, Korabecny J. Konecny J, et al. Among authors: prchal l. Biomolecules. 2020 Dec 22;11(1):3. doi: 10.3390/biom11010003. Biomolecules. 2020. PMID: 33375115 Free PMC article.
Development of versatile and potent monoquaternary reactivators of acetylcholinesterase.
Gorecki L, Hepnarova V, Karasova JZ, Hrabinova M, Courageux C, Dias J, Kucera T, Kobrlova T, Muckova L, Prchal L, Malinak D, Jun D, Musilek K, Worek F, Nachon F, Soukup O, Korabecny J. Gorecki L, et al. Among authors: prchal l. Arch Toxicol. 2021 Mar;95(3):985-1001. doi: 10.1007/s00204-021-02981-w. Epub 2021 Jan 31. Arch Toxicol. 2021. PMID: 33517499
47 results