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PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
Ren AA, Snellings DA, Su YS, Hong CC, Castro M, Tang AT, Detter MR, Hobson N, Girard R, Romanos S, Lightle R, Moore T, Shenkar R, Benavides C, Beaman MM, Müller-Fielitz H, Chen M, Mericko P, Yang J, Sung DC, Lawton MT, Ruppert JM, Schwaninger M, Körbelin J, Potente M, Awad IA, Marchuk DA, Kahn ML. Ren AA, et al. Among authors: hobson n. Nature. 2021 Jun;594(7862):271-276. doi: 10.1038/s41586-021-03562-8. Epub 2021 Apr 28. Nature. 2021. PMID: 33910229 Free PMC article.
Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.
Tang AT, Choi JP, Kotzin JJ, Yang Y, Hong CC, Hobson N, Girard R, Zeineddine HA, Lightle R, Moore T, Cao Y, Shenkar R, Chen M, Mericko P, Yang J, Li L, Tanes C, Kobuley D, Võsa U, Whitehead KJ, Li DY, Franke L, Hart B, Schwaninger M, Henao-Mejia J, Morrison L, Kim H, Awad IA, Zheng X, Kahn ML. Tang AT, et al. Among authors: hobson n. Nature. 2017 May 18;545(7654):305-310. doi: 10.1038/nature22075. Epub 2017 May 10. Nature. 2017. PMID: 28489816 Free PMC article.
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.
Hong CC, Tang AT, Detter MR, Choi JP, Wang R, Yang X, Guerrero AA, Wittig CF, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Goddard LM, Ren AA, Leu NA, Sterling S, Yang J, Li L, Chen M, Mericko-Ishizuka P, Dow LE, Watanabe H, Schwaninger M, Min W, Marchuk DA, Zheng X, Awad IA, Kahn ML. Hong CC, et al. Among authors: hobson n. J Exp Med. 2020 Oct 5;217(10):e20200140. doi: 10.1084/jem.20200140. J Exp Med. 2020. PMID: 32648916 Free PMC article.
Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.
Shenkar R, Peiper A, Pardo H, Moore T, Lightle R, Girard R, Hobson N, Polster SP, Koskimäki J, Zhang D, Lyne SB, Cao Y, Chaudagar K, Saadat L, Gallione C, Pytel P, Liao JK, Marchuk D, Awad IA. Shenkar R, et al. Among authors: hobson n. Stroke. 2019 Mar;50(3):738-744. doi: 10.1161/STROKEAHA.118.024058. Stroke. 2019. PMID: 30744543 Free PMC article.
A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease.
McKerracher L, Shenkar R, Abbinanti M, Cao Y, Peiper A, Liao JK, Lightle R, Moore T, Hobson N, Gallione C, Ruschel J, Koskimäki J, Girard R, Rosen K, Marchuk DA, Awad IA. McKerracher L, et al. Among authors: hobson n. Transl Stroke Res. 2020 Jun;11(3):365-376. doi: 10.1007/s12975-019-00725-8. Epub 2019 Aug 24. Transl Stroke Res. 2020. PMID: 31446620 Free PMC article.
Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.
Tang AT, Sullivan KR, Hong CC, Goddard LM, Mahadevan A, Ren A, Pardo H, Peiper A, Griffin E, Tanes C, Mattei LM, Yang J, Li L, Mericko-Ishizuka P, Shen L, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Rödel CJ, Li N, Zhu Q, Whitehead KJ, Zheng X, Akers A, Morrison L, Kim H, Bittinger K, Lengner CJ, Schwaninger M, Velcich A, Augenlicht L, Abdelilah-Seyfried S, Min W, Marchuk DA, Awad IA, Kahn ML. Tang AT, et al. Among authors: hobson n. Sci Transl Med. 2019 Nov 27;11(520):eaaw3521. doi: 10.1126/scitranslmed.aaw3521. Sci Transl Med. 2019. PMID: 31776290 Free PMC article.
Novel Murine Models of Cerebral Cavernous Malformations.
Detter MR, Shenkar R, Benavides CR, Neilson CA, Moore T, Lightle R, Hobson N, Shen L, Cao Y, Girard R, Zhang D, Griffin E, Gallione CJ, Awad IA, Marchuk DA. Detter MR, et al. Among authors: hobson n. Angiogenesis. 2020 Nov;23(4):651-666. doi: 10.1007/s10456-020-09736-8. Epub 2020 Jul 24. Angiogenesis. 2020. PMID: 32710309 Free PMC article.
Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation.
Lopez-Ramirez MA, Lai CC, Soliman SI, Hale P, Pham A, Estrada EJ, McCurdy S, Girard R, Verma R, Moore T, Lightle R, Hobson N, Shenkar R, Poulsen O, Haddad GG, Daneman R, Gongol B, Sun H, Lagarrigue F, Awad IA, Ginsberg MH. Lopez-Ramirez MA, et al. Among authors: hobson n. J Clin Invest. 2021 Jul 1;131(13):e139570. doi: 10.1172/JCI139570. J Clin Invest. 2021. PMID: 34043589 Free PMC article.
Propranolol as therapy for cerebral cavernous malformations: a cautionary note.
Shenkar R, Moore T, Benavides C, Lightle R, Detter MR, Hobson N, Girard R, DeBiasse D, Patrucco M, Gallione C, Zabramski JM, Marchuk DA, Awad IA. Shenkar R, et al. Among authors: hobson n. J Transl Med. 2022 Apr 5;20(1):160. doi: 10.1186/s12967-022-03360-4. J Transl Med. 2022. PMID: 35382850 Free PMC article. No abstract available.
84 results