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PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
Ren AA, Snellings DA, Su YS, Hong CC, Castro M, Tang AT, Detter MR, Hobson N, Girard R, Romanos S, Lightle R, Moore T, Shenkar R, Benavides C, Beaman MM, Müller-Fielitz H, Chen M, Mericko P, Yang J, Sung DC, Lawton MT, Ruppert JM, Schwaninger M, Körbelin J, Potente M, Awad IA, Marchuk DA, Kahn ML. Ren AA, et al. Among authors: korbelin j. Nature. 2021 Jun;594(7862):271-276. doi: 10.1038/s41586-021-03562-8. Epub 2021 Apr 28. Nature. 2021. PMID: 33910229 Free PMC article.
Genetic manipulation of brain endothelial cells in vivo.
Assmann JC, Körbelin J, Schwaninger M. Assmann JC, et al. Among authors: korbelin j. Biochim Biophys Acta. 2016 Mar;1862(3):381-94. doi: 10.1016/j.bbadis.2015.10.006. Epub 2015 Oct 8. Biochim Biophys Acta. 2016. PMID: 26454206 Free article. Review. No abstract available.
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1.
Yousef H, Czupalla CJ, Lee D, Chen MB, Burke AN, Zera KA, Zandstra J, Berber E, Lehallier B, Mathur V, Nair RV, Bonanno LN, Yang AC, Peterson T, Hadeiba H, Merkel T, Körbelin J, Schwaninger M, Buckwalter MS, Quake SR, Butcher EC, Wyss-Coray T. Yousef H, et al. Among authors: korbelin j. Nat Med. 2019 Jun;25(6):988-1000. doi: 10.1038/s41591-019-0440-4. Epub 2019 May 13. Nat Med. 2019. PMID: 31086348 Free PMC article.
Short regulatory DNA sequences to target brain endothelial cells for gene therapy.
Graßhoff H, Müller-Fielitz H, Dogbevia GK, Körbelin J, Bannach J, Vahldieck CM, Kusche-Vihrog K, Jöhren O, Müller OJ, Nogueiras R, Prevot V, Schwaninger M. Graßhoff H, et al. Among authors: korbelin j. J Cereb Blood Flow Metab. 2022 Jan;42(1):104-120. doi: 10.1177/0271678X211039617. Epub 2021 Aug 24. J Cereb Blood Flow Metab. 2022. PMID: 34427142 Free PMC article.
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.
Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, Krohn M, Körbelin J, Zhang L, Özorhan Ü, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, Fähnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Coêlho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, König P, Busch H, Collin L, Villaseñor R, Jöhren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, Püschel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M. Wenzel J, et al. Among authors: korbelin j. Nat Neurosci. 2021 Nov;24(11):1522-1533. doi: 10.1038/s41593-021-00926-1. Epub 2021 Oct 21. Nat Neurosci. 2021. PMID: 34675436 Free PMC article.
Gene therapy decreases seizures in a model of Incontinentia pigmenti.
Dogbevia GK, Töllner K, Körbelin J, Bröer S, Ridder DA, Grasshoff H, Brandt C, Wenzel J, Straub BK, Trepel M, Löscher W, Schwaninger M. Dogbevia GK, et al. Among authors: korbelin j. Ann Neurol. 2017 Jul;82(1):93-104. doi: 10.1002/ana.24981. Ann Neurol. 2017. PMID: 28628231
44 results