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The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake.
de Mingo Pulido Á, Hänggi K, Celias DP, Gardner A, Li J, Batista-Bittencourt B, Mohamed E, Trillo-Tinoco J, Osunmakinde O, Peña R, Onimus A, Kaisho T, Kaufmann J, McEachern K, Soliman H, Luca VC, Rodriguez PC, Yu X, Ruffell B. de Mingo Pulido Á, et al. Among authors: ruffell b. Immunity. 2021 Jun 8;54(6):1154-1167.e7. doi: 10.1016/j.immuni.2021.04.019. Epub 2021 May 11. Immunity. 2021. PMID: 33979578 Free PMC article.
Dendritic Cells and Cancer Immunity.
Gardner A, Ruffell B. Gardner A, et al. Among authors: ruffell b. Trends Immunol. 2016 Dec;37(12):855-865. doi: 10.1016/j.it.2016.09.006. Epub 2016 Oct 25. Trends Immunol. 2016. PMID: 27793569 Free PMC article. Review.
Reducing interferon'ce in stem cells.
Gardner A, Ruffell B. Gardner A, et al. Among authors: ruffell b. Nat Cell Biol. 2017 May 31;19(6):597-599. doi: 10.1038/ncb3544. Nat Cell Biol. 2017. PMID: 28561058
moDCs, Less Problems.
Gardner A, Ruffell B. Gardner A, et al. Among authors: ruffell b. Immunity. 2018 Jan 16;48(1):6-8. doi: 10.1016/j.immuni.2017.12.017. Immunity. 2018. PMID: 29343441 Free article.
AMPK Alpha-1 Intrinsically Regulates the Function and Differentiation of Tumor Myeloid-Derived Suppressor Cells.
Trillo-Tinoco J, Sierra RA, Mohamed E, Cao Y, de Mingo-Pulido Á, Gilvary DL, Anadon CM, Costich TL, Wei S, Flores ER, Ruffell B, Conejo-Garcia JR, Rodriguez PC. Trillo-Tinoco J, et al. Among authors: ruffell b. Cancer Res. 2019 Oct 1;79(19):5034-5047. doi: 10.1158/0008-5472.CAN-19-0880. Epub 2019 Aug 13. Cancer Res. 2019. PMID: 31409640 Free PMC article.
The Immune Microenvironment and Cancer Metastasis.
El-Kenawi A, Hänggi K, Ruffell B. El-Kenawi A, et al. Among authors: ruffell b. Cold Spring Harb Perspect Med. 2020 Apr 1;10(4):a037424. doi: 10.1101/cshperspect.a037424. Cold Spring Harb Perspect Med. 2020. PMID: 31501262 Free PMC article. Review.
The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling.
Mohamed E, Sierra RA, Trillo-Tinoco J, Cao Y, Innamarato P, Payne KK, de Mingo Pulido A, Mandula J, Zhang S, Thevenot P, Biswas S, Abdalla SK, Costich TL, Hänggi K, Anadon CM, Flores ER, Haura EB, Mehrotra S, Pilon-Thomas S, Ruffell B, Munn DH, Cubillos-Ruiz JR, Conejo-Garcia JR, Rodriguez PC. Mohamed E, et al. Among authors: ruffell b. Immunity. 2020 Apr 14;52(4):668-682.e7. doi: 10.1016/j.immuni.2020.03.004. Immunity. 2020. PMID: 32294407 Free PMC article.
60 results