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Epigenetic analysis of patients with T-ALL identifies poor outcomes and a hypomethylating agent-responsive subgroup.
Touzart A, Mayakonda A, Smith C, Hey J, Toth R, Cieslak A, Andrieu GP, Tran Quang C, Latiri M, Ghysdael J, Spicuglia S, Dombret H, Ifrah N, Macintyre E, Lutsik P, Boissel N, Plass C, Asnafi V. Touzart A, et al. Among authors: spicuglia s. Sci Transl Med. 2021 May 26;13(595):eabc4834. doi: 10.1126/scitranslmed.abc4834. Sci Transl Med. 2021. PMID: 34039737 Free article. Clinical Trial.
TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression.
Dadi S, Le Noir S, Payet-Bornet D, Lhermitte L, Zacarias-Cabeza J, Bergeron J, Villarèse P, Vachez E, Dik WA, Millien C, Radford I, Verhoeyen E, Cosset FL, Petit A, Ifrah N, Dombret H, Hermine O, Spicuglia S, Langerak AW, Macintyre EA, Nadel B, Ferrier P, Asnafi V. Dadi S, et al. Among authors: spicuglia s. Cancer Cell. 2012 Apr 17;21(4):563-76. doi: 10.1016/j.ccr.2012.02.013. Cancer Cell. 2012. PMID: 22516263 Free article.
Extensive molecular mapping of TCRα/δ- and TCRβ-involved chromosomal translocations reveals distinct mechanisms of oncogene activation in T-ALL.
Le Noir S, Ben Abdelali R, Lelorch M, Bergeron J, Sungalee S, Payet-Bornet D, Villarèse P, Petit A, Callens C, Lhermitte L, Baranger L, Radford-Weiss I, Grégoire MJ, Dombret H, Ifrah N, Spicuglia S, Romana S, Soulier J, Nadel B, Macintyre E, Asnafi V. Le Noir S, et al. Among authors: spicuglia s. Blood. 2012 Oct 18;120(16):3298-309. doi: 10.1182/blood-2012-04-425488. Epub 2012 Sep 4. Blood. 2012. PMID: 22948044 Free article.
RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangement.
Cieslak A, Le Noir S, Trinquand A, Lhermitte L, Franchini DM, Villarese P, Gon S, Bond J, Simonin M, Vanhille L, Reimann C, Verhoeyen E, Larghero J, Six E, Spicuglia S, André-Schmutz I, Langerak A, Nadel B, Macintyre E, Payet-Bornet D, Asnafi V. Cieslak A, et al. Among authors: spicuglia s. J Exp Med. 2014 Aug 25;211(9):1821-32. doi: 10.1084/jem.20132585. Epub 2014 Aug 18. J Exp Med. 2014. PMID: 25135298 Free PMC article.
An early thymic precursor phenotype predicts outcome exclusively in HOXA-overexpressing adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study.
Bond J, Marchand T, Touzart A, Cieslak A, Trinquand A, Sutton L, Radford-Weiss I, Lhermitte L, Spicuglia S, Dombret H, Macintyre E, Ifrah N, Hamel JF, Asnafi V. Bond J, et al. Among authors: spicuglia s. Haematologica. 2016 Jun;101(6):732-40. doi: 10.3324/haematol.2015.141218. Epub 2016 Mar 4. Haematologica. 2016. PMID: 26944475 Free PMC article. Clinical Trial.
Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppressive Pathway in T-cell Leukemia.
Trinquand A, Dos Santos NR, Tran Quang C, Rocchetti F, Zaniboni B, Belhocine M, Da Costa de Jesus C, Lhermitte L, Tesio M, Dussiot M, Cosset FL, Verhoeyen E, Pflumio F, Ifrah N, Dombret H, Spicuglia S, Chatenoud L, Gross DA, Hermine O, Macintyre E, Ghysdael J, Asnafi V. Trinquand A, et al. Among authors: spicuglia s. Cancer Discov. 2016 Sep;6(9):972-85. doi: 10.1158/2159-8290.CD-15-0675. Epub 2016 Jun 28. Cancer Discov. 2016. PMID: 27354269
TCRα rearrangements identify a subgroup of NKL-deregulated adult T-ALLs associated with favorable outcome.
Villarese P, Lours C, Trinquand A, Le Noir S, Belhocine M, Lhermitte L, Cieslak A, Tesio M, Petit A, LeLorch M, Spicuglia S, Ifrah N, Dombret H, Langerak AW, Boissel N, Macintyre E, Asnafi V. Villarese P, et al. Among authors: spicuglia s. Leukemia. 2018 Jan;32(1):61-71. doi: 10.1038/leu.2017.176. Epub 2017 Jun 8. Leukemia. 2018. PMID: 28592888 Clinical Trial.
Early Response-Based Therapy Stratification Improves Survival in Adult Early Thymic Precursor Acute Lymphoblastic Leukemia: A Group for Research on Adult Acute Lymphoblastic Leukemia Study.
Bond J, Graux C, Lhermitte L, Lara D, Cluzeau T, Leguay T, Cieslak A, Trinquand A, Pastoret C, Belhocine M, Spicuglia S, Lheritier V, Leprêtre S, Thomas X, Huguet F, Ifrah N, Dombret H, Macintyre E, Boissel N, Asnafi V. Bond J, et al. Among authors: spicuglia s. J Clin Oncol. 2017 Aug 10;35(23):2683-2691. doi: 10.1200/JCO.2016.71.8585. Epub 2017 Jun 12. J Clin Oncol. 2017. PMID: 28605290 Clinical Trial.
Homeobox protein TLX3 activates miR-125b expression to promote T-cell acute lymphoblastic leukemia.
Renou L, Boelle PY, Deswarte C, Spicuglia S, Benyoucef A, Calvo J, Uzan B, Belhocine M, Cieslak A, Landman-Parker J, Baruchel A, Asnafi V, Pflumio F, Ballerini P, Naguibneva I. Renou L, et al. Among authors: spicuglia s. Blood Adv. 2017 May 4;1(12):733-747. doi: 10.1182/bloodadvances.2017005538. eCollection 2017 May 9. Blood Adv. 2017. PMID: 29296717 Free PMC article.
90 results