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GABAA Alpha 2,3 Modulation Improves Select Phenotypes in a Mouse Model of Fragile X Syndrome.
Schaefer TL, Ashworth AA, Tiwari D, Tomasek MP, Parkins EV, White AR, Snider A, Davenport MH, Grainger LM, Becker RA, Robinson CK, Mukherjee R, Williams MT, Gibson JR, Huber KM, Gross C, Erickson CA. Schaefer TL, et al. Front Psychiatry. 2021 May 21;12:678090. doi: 10.3389/fpsyt.2021.678090. eCollection 2021. Front Psychiatry. 2021. PMID: 34093287 Free PMC article.
The potassium channel Kv4.2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice.
Tiwari D, Schaefer TL, Schroeder-Carter LM, Krzeski JC, Bunk AT, Parkins EV, Snider A, Danzer R, Williams MT, Vorhees CV, Danzer SC, Gross C. Tiwari D, et al. Among authors: schaefer tl. Exp Neurol. 2020 Dec;334:113437. doi: 10.1016/j.expneurol.2020.113437. Epub 2020 Aug 19. Exp Neurol. 2020. PMID: 32822706 Free PMC article.
Pharmacotherapy for Fragile X Syndrome: Progress to Date.
Davenport MH, Schaefer TL, Friedmann KJ, Fitzpatrick SE, Erickson CA. Davenport MH, et al. Among authors: schaefer tl. Drugs. 2016 Mar;76(4):431-45. doi: 10.1007/s40265-016-0542-y. Drugs. 2016. PMID: 26858239 Review.
Fragile X targeted pharmacotherapy: lessons learned and future directions.
Erickson CA, Davenport MH, Schaefer TL, Wink LK, Pedapati EV, Sweeney JA, Fitzpatrick SE, Brown WT, Budimirovic D, Hagerman RJ, Hessl D, Kaufmann WE, Berry-Kravis E. Erickson CA, et al. Among authors: schaefer tl. J Neurodev Disord. 2017 Jun 12;9:7. doi: 10.1186/s11689-017-9186-9. eCollection 2017. J Neurodev Disord. 2017. PMID: 28616096 Free PMC article. Review.
Mouse plasmacytoma-expressed transcript 1 knock out induced 5-HT disruption results in a lack of cognitive deficits and an anxiety phenotype complicated by hypoactivity and defensiveness.
Schaefer TL, Vorhees CV, Williams MT. Schaefer TL, et al. Neuroscience. 2009 Dec 29;164(4):1431-43. doi: 10.1016/j.neuroscience.2009.09.059. Epub 2009 Sep 25. Neuroscience. 2009. PMID: 19786075 Free PMC article.
These findings were unexpected given that 5-HT depleting drugs given to adult or developing animals result in learning deficits [Mazer C, Muneyyirci J, Taheny K, Raio N, Borella A, Whitaker-Azmitia P (1997) Brain Res 760:68-73; Morford LL, Inman-Wood SL, Gudelsky GA, Williams MT, …
These findings were unexpected given that 5-HT depleting drugs given to adult or developing animals result in learning deficits [Mazer C, Mu …
Impact of acamprosate on plasma amyloid-β precursor protein in youth: a pilot analysis in fragile X syndrome-associated and idiopathic autism spectrum disorder suggests a pharmacodynamic protein marker.
Erickson CA, Ray B, Maloney B, Wink LK, Bowers K, Schaefer TL, McDougle CJ, Sokol DK, Lahiri DK. Erickson CA, et al. Among authors: schaefer tl. J Psychiatr Res. 2014 Dec;59:220-8. doi: 10.1016/j.jpsychires.2014.07.011. Epub 2014 Aug 19. J Psychiatr Res. 2014. PMID: 25300441 Free PMC article.
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