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CD3G or CD3D Knockdown in Mature, but Not Immature, T Lymphocytes Similarly Cripples the Human TCRαβ Complex.
Garcillán B, Fuentes P, Marin AV, Megino RF, Chacon-Arguedas D, Mazariegos MS, Jiménez-Reinoso A, Muñoz-Ruiz M, Laborda RG, Cárdenas PP, Fernández-Malavé E, Toribio ML, Regueiro JR. Garcillán B, et al. Among authors: regueiro jr. Front Cell Dev Biol. 2021 Jun 25;9:608490. doi: 10.3389/fcell.2021.608490. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34249896 Free PMC article.
Differential antibody binding to the surface alphabetaTCR.CD3 complex of CD4+ and CD8+ T lymphocytes is conserved in mammals and associated with differential glycosylation.
Rossi NE, Reiné J, Pineda-Lezamit M, Pulgar M, Meza NW, Swamy M, Risueno R, Schamel WW, Bonay P, Fernández-Malavé E, Regueiro JR. Rossi NE, et al. Among authors: regueiro jr. Int Immunol. 2008 Oct;20(10):1247-58. doi: 10.1093/intimm/dxn081. Epub 2008 Jul 24. Int Immunol. 2008. PMID: 18653700
A leaky mutation in CD3D differentially affects αβ and γδ T cells and leads to a Tαβ-Tγδ+B+NK+ human SCID.
Gil J, Busto EM, Garcillán B, Chean C, García-Rodríguez MC, Díaz-Alderete A, Navarro J, Reiné J, Mencía A, Gurbindo D, Beléndez C, Gordillo I, Duchniewicz M, Höhne K, García-Sánchez F, Fernández-Cruz E, López-Granados E, Schamel WW, Moreno-Pelayo MA, Recio MJ, Regueiro JR. Gil J, et al. Among authors: regueiro jr. J Clin Invest. 2011 Oct;121(10):3872-6. doi: 10.1172/JCI44254. Epub 2011 Sep 19. J Clin Invest. 2011. PMID: 21926461 Free PMC article.
New tools in regenerative medicine: gene therapy.
Muñoz Ruiz M, Regueiro JR. Muñoz Ruiz M, et al. Among authors: regueiro jr. Adv Exp Med Biol. 2012;741:254-75. doi: 10.1007/978-1-4614-2098-9_17. Adv Exp Med Biol. 2012. PMID: 22457115
Human CD3γ, but not CD3δ, haploinsufficiency differentially impairs γδ versus αβ surface TCR expression.
Muñoz-Ruiz M, Pérez-Flores V, Garcillán B, Guardo AC, Mazariegos MS, Takada H, Allende LM, Kilic SS, Sanal O, Roifman CM, López-Granados E, Recio MJ, Martínez-Naves E, Fernández-Malavé E, Regueiro JR. Muñoz-Ruiz M, et al. Among authors: regueiro jr. BMC Immunol. 2013 Jan 21;14:3. doi: 10.1186/1471-2172-14-3. BMC Immunol. 2013. PMID: 23336327 Free PMC article.
115 results