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Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies.
Jung S, Fuchs N, Johe P, Wagner A, Diehl E, Yuliani T, Zimmer C, Barthels F, Zimmermann RA, Klein P, Waigel W, Meyr J, Opatz T, Tenzer S, Distler U, Räder HJ, Kersten C, Engels B, Hellmich UA, Klein J, Schirmeister T. Jung S, et al. Among authors: opatz t. J Med Chem. 2021 Aug 26;64(16):12322-12358. doi: 10.1021/acs.jmedchem.1c01002. Epub 2021 Aug 11. J Med Chem. 2021. PMID: 34378914
Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes.
Wagner A, Le TA, Brennich M, Klein P, Bader N, Diehl E, Paszek D, Weickhmann AK, Dirdjaja N, Krauth-Siegel RL, Engels B, Opatz T, Schindelin H, Hellmich UA. Wagner A, et al. Among authors: opatz t. Angew Chem Int Ed Engl. 2019 Mar 11;58(11):3640-3644. doi: 10.1002/anie.201810470. Epub 2019 Jan 30. Angew Chem Int Ed Engl. 2019. PMID: 30605929
214 results