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Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation.
Lanz AL, Masi G, Porciello N, Cohnen A, Cipria D, Prakaash D, Bálint Š, Raggiaschi R, Galgano D, Cole DK, Lepore M, Dushek O, Dustin ML, Sansom MSP, Kalli AC, Acuto O. Lanz AL, et al. Among authors: dushek o. Cell Rep. 2021 Aug 10;36(6):109531. doi: 10.1016/j.celrep.2021.109531. Cell Rep. 2021. PMID: 34380025 Free PMC article. No abstract available.
CD8 helps TCR catch slippery self pMHC.
Dushek O, Dustin ML. Dushek O, et al. Nat Immunol. 2018 Dec;19(12):1280-1281. doi: 10.1038/s41590-018-0261-5. Nat Immunol. 2018. PMID: 30420625 No abstract available.
A THEMIS:SHP1 complex promotes T-cell survival.
Paster W, Bruger AM, Katsch K, Grégoire C, Roncagalli R, Fu G, Gascoigne NR, Nika K, Cohnen A, Feller SM, Simister PC, Molder KC, Cordoba SP, Dushek O, Malissen B, Acuto O. Paster W, et al. Among authors: dushek o. EMBO J. 2015 Feb 3;34(3):393-409. doi: 10.15252/embj.201387725. Epub 2014 Dec 22. EMBO J. 2015. PMID: 25535246 Free PMC article.
The discriminatory power of the T cell receptor.
Pettmann J, Huhn A, Abu Shah E, Kutuzov MA, Wilson DB, Dustin ML, Davis SJ, van der Merwe PA, Dushek O. Pettmann J, et al. Among authors: dushek o. Elife. 2021 May 25;10:e67092. doi: 10.7554/eLife.67092. Elife. 2021. PMID: 34030769 Free PMC article.
Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor.
Goyette J, Depoil D, Yang Z, Isaacson SA, Allard J, van der Merwe PA, Gaus K, Dustin ML, Dushek O. Goyette J, et al. Among authors: dushek o. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2116815119. doi: 10.1073/pnas.2116815119. Proc Natl Acad Sci U S A. 2022. PMID: 35197288 Free PMC article.
Using CombiCells, a platform for titration and combinatorial display of cell surface ligands, to study T-cell antigen sensitivity modulation by accessory receptors.
Patel A, Andre V, Eguiguren SB, Barton MI, Burton J, Denham EM, Pettmann J, Mørch AM, Kutuzov MA, Siller-Farfán JA, Dustin ML, van der Merwe PA, Dushek O. Patel A, et al. Among authors: dushek o. EMBO J. 2024 Jan;43(1):132-150. doi: 10.1038/s44318-023-00012-1. Epub 2023 Dec 18. EMBO J. 2024. PMID: 38177315 Free PMC article.
65 results