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Page 1
RSPO3 is important for trabecular bone and fracture risk in mice and humans.
Nilsson KH, Henning P, El Shahawy M, Nethander M, Andersen TL, Ejersted C, Wu J, Gustafsson KL, Koskela A, Tuukkanen J, Souza PPC, Tuckermann J, Lorentzon M, Ruud LE, Lehtimäki T, Tobias JH, Zhou S, Lerner UH, Richards JB, Movérare-Skrtic S, Ohlsson C. Nilsson KH, et al. Among authors: tobias jh. Nat Commun. 2021 Aug 13;12(1):4923. doi: 10.1038/s41467-021-25124-2. Nat Commun. 2021. PMID: 34389713 Free PMC article.
Common variants in the region around Osterix are associated with bone mineral density and growth in childhood.
Timpson NJ, Tobias JH, Richards JB, Soranzo N, Duncan EL, Sims AM, Whittaker P, Kumanduri V, Zhai G, Glaser B, Eisman J, Jones G, Nicholson G, Prince R, Seeman E, Spector TD, Brown MA, Peltonen L, Smith GD, Deloukas P, Evans DM. Timpson NJ, et al. Among authors: tobias jh. Hum Mol Genet. 2009 Apr 15;18(8):1510-7. doi: 10.1093/hmg/ddp052. Epub 2009 Jan 30. Hum Mol Genet. 2009. PMID: 19181680 Free PMC article.
OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts.
Paternoster L, Ohlsson C, Sayers A, Vandenput L, Lorentzon M, Evans DM, Tobias JH. Paternoster L, et al. Among authors: tobias jh. J Clin Endocrinol Metab. 2010 Aug;95(8):3940-8. doi: 10.1210/jc.2010-0025. Epub 2010 Jun 9. J Clin Endocrinol Metab. 2010. PMID: 20534768 Free PMC article.
Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone.
Paternoster L, Lorentzon M, Vandenput L, Karlsson MK, Ljunggren O, Kindmark A, Mellstrom D, Kemp JP, Jarett CE, Holly JM, Sayers A, St Pourcain B, Timpson NJ, Deloukas P, Davey Smith G, Ring SM, Evans DM, Tobias JH, Ohlsson C. Paternoster L, et al. Among authors: tobias jh. PLoS Genet. 2010 Nov 18;6(11):e1001217. doi: 10.1371/journal.pgen.1001217. PLoS Genet. 2010. PMID: 21124946 Free PMC article.
Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.
Medina-Gomez C, Kemp JP, Estrada K, Eriksson J, Liu J, Reppe S, Evans DM, Heppe DH, Vandenput L, Herrera L, Ring SM, Kruithof CJ, Timpson NJ, Zillikens MC, Olstad OK, Zheng HF, Richards JB, St Pourcain B, Hofman A, Jaddoe VW, Smith GD, Lorentzon M, Gautvik KM, Uitterlinden AG, Brommage R, Ohlsson C, Tobias JH, Rivadeneira F. Medina-Gomez C, et al. Among authors: tobias jh. PLoS Genet. 2012 Jul;8(7):e1002718. doi: 10.1371/journal.pgen.1002718. Epub 2012 Jul 5. PLoS Genet. 2012. PMID: 22792070 Free PMC article.
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk.
Zheng HF, Tobias JH, Duncan E, Evans DM, Eriksson J, Paternoster L, Yerges-Armstrong LM, Lehtimäki T, Bergström U, Kähönen M, Leo PJ, Raitakari O, Laaksonen M, Nicholson GC, Viikari J, Ladouceur M, Lyytikäinen LP, Medina-Gomez C, Rivadeneira F, Prince RL, Sievanen H, Leslie WD, Mellström D, Eisman JA, Movérare-Skrtic S, Goltzman D, Hanley DA, Jones G, St Pourcain B, Xiao Y, Timpson NJ, Smith GD, Reid IR, Ring SM, Sambrook PN, Karlsson M, Dennison EM, Kemp JP, Danoy P, Sayers A, Wilson SG, Nethander M, McCloskey E, Vandenput L, Eastell R, Liu J, Spector T, Mitchell BD, Streeten EA, Brommage R, Pettersson-Kymmer U, Brown MA, Ohlsson C, Richards JB, Lorentzon M. Zheng HF, et al. Among authors: tobias jh. PLoS Genet. 2012 Jul;8(7):e1002745. doi: 10.1371/journal.pgen.1002745. Epub 2012 Jul 5. PLoS Genet. 2012. PMID: 22792071 Free PMC article.
Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure.
Paternoster L, Lorentzon M, Lehtimäki T, Eriksson J, Kähönen M, Raitakari O, Laaksonen M, Sievänen H, Viikari J, Lyytikäinen LP, Mellström D, Karlsson M, Ljunggren O, Grundberg E, Kemp JP, Sayers A, Nethander M, Evans DM, Vandenput L, Tobias JH, Ohlsson C. Paternoster L, et al. Among authors: tobias jh. PLoS Genet. 2013;9(2):e1003247. doi: 10.1371/journal.pgen.1003247. Epub 2013 Feb 21. PLoS Genet. 2013. PMID: 23437003 Free PMC article.
Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of β-C-telopeptides of type I collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT.
Kemp JP, Sayers A, Paternoster L, Evans DM, Deere K, St Pourcain B, Timpson NJ, Ring SM, Lorentzon M, Lehtimäki T, Eriksson J, Kähönen M, Raitakari O, Laaksonen M, Sievänen H, Viikari J, Lyytikäinen LP, Smith GD, Fraser WD, Vandenput L, Ohlsson C, Tobias JH. Kemp JP, et al. Among authors: tobias jh. J Bone Miner Res. 2014 Apr;29(4):1015-24. doi: 10.1002/jbmr.2093. J Bone Miner Res. 2014. PMID: 24014423 Free PMC article.
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.
Zheng HF, Forgetta V, Hsu YH, Estrada K, Rosello-Diez A, Leo PJ, Dahia CL, Park-Min KH, Tobias JH, Kooperberg C, Kleinman A, Styrkarsdottir U, Liu CT, Uggla C, Evans DS, Nielson CM, Walter K, Pettersson-Kymmer U, McCarthy S, Eriksson J, Kwan T, Jhamai M, Trajanoska K, Memari Y, Min J, Huang J, Danecek P, Wilmot B, Li R, Chou WC, Mokry LE, Moayyeri A, Claussnitzer M, Cheng CH, Cheung W, Medina-Gómez C, Ge B, Chen SH, Choi K, Oei L, Fraser J, Kraaij R, Hibbs MA, Gregson CL, Paquette D, Hofman A, Wibom C, Tranah GJ, Marshall M, Gardiner BB, Cremin K, Auer P, Hsu L, Ring S, Tung JY, Thorleifsson G, Enneman AW, van Schoor NM, de Groot LC, van der Velde N, Melin B, Kemp JP, Christiansen C, Sayers A, Zhou Y, Calderari S, van Rooij J, Carlson C, Peters U, Berlivet S, Dostie J, Uitterlinden AG, Williams SR, Farber C, Grinberg D, LaCroix AZ, Haessler J, Chasman DI, Giulianini F, Rose LM, Ridker PM, Eisman JA, Nguyen TV, Center JR, Nogues X, Garcia-Giralt N, Launer LL, Gudnason V, Mellström D, Vandenput L, Amin N, van Duijn CM, Karlsson MK, Ljunggren Ö, Svensson O, Hallmans G, Rousseau F, Giroux S, Bussière J, Arp PP, Koromani F, Prince RL, Lewis JR, Langdahl BL, Hermann AP, Jensen JE… See abstract for full author list ➔ Zheng HF, et al. Among authors: tobias jh. Nature. 2015 Oct 1;526(7571):112-7. doi: 10.1038/nature14878. Epub 2015 Sep 14. Nature. 2015. PMID: 26367794 Free PMC article.
Epigenome-wide Association of DNA Methylation in Whole Blood With Bone Mineral Density.
Morris JA, Tsai PC, Joehanes R, Zheng J, Trajanoska K, Soerensen M, Forgetta V, Castillo-Fernandez JE, Frost M, Spector TD, Christensen K, Christiansen L, Rivadeneira F, Tobias JH, Evans DM, Kiel DP, Hsu YH, Richards JB, Bell JT. Morris JA, et al. Among authors: tobias jh. J Bone Miner Res. 2017 Aug;32(8):1644-1650. doi: 10.1002/jbmr.3148. Epub 2017 May 8. J Bone Miner Res. 2017. PMID: 28394087 Free PMC article. Clinical Trial.
262 results