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RSPO3 is important for trabecular bone and fracture risk in mice and humans.
Nilsson KH, Henning P, El Shahawy M, Nethander M, Andersen TL, Ejersted C, Wu J, Gustafsson KL, Koskela A, Tuukkanen J, Souza PPC, Tuckermann J, Lorentzon M, Ruud LE, Lehtimäki T, Tobias JH, Zhou S, Lerner UH, Richards JB, Movérare-Skrtic S, Ohlsson C. Nilsson KH, et al. Among authors: tuckermann j. Nat Commun. 2021 Aug 13;12(1):4923. doi: 10.1038/s41467-021-25124-2. Nat Commun. 2021. PMID: 34389713 Free PMC article.
Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures.
Movérare-Skrtic S, Henning P, Liu X, Nagano K, Saito H, Börjesson AE, Sjögren K, Windahl SH, Farman H, Kindlund B, Engdahl C, Koskela A, Zhang FP, Eriksson EE, Zaman F, Hammarstedt A, Isaksson H, Bally M, Kassem A, Lindholm C, Sandberg O, Aspenberg P, Sävendahl L, Feng JQ, Tuckermann J, Tuukkanen J, Poutanen M, Baron R, Lerner UH, Gori F, Ohlsson C. Movérare-Skrtic S, et al. Among authors: tuckermann j. Nat Med. 2014 Nov;20(11):1279-88. doi: 10.1038/nm.3654. Epub 2014 Oct 12. Nat Med. 2014. PMID: 25306233 Free PMC article.
Loss of menin in osteoblast lineage affects osteocyte-osteoclast crosstalk causing osteoporosis.
Liu P, Lee S, Knoll J, Rauch A, Ostermay S, Luther J, Malkusch N, Lerner UH, Zaiss MM, Neven M, Wittig R, Rauner M, David JP, Bertolino P, Zhang CX, Tuckermann JP. Liu P, et al. Among authors: tuckermann jp. Cell Death Differ. 2017 Apr;24(4):672-682. doi: 10.1038/cdd.2016.165. Epub 2017 Jan 20. Cell Death Differ. 2017. PMID: 28106886 Free PMC article.
Osteoblast-derived NOTUM reduces cortical bone mass in mice and the NOTUM locus is associated with bone mineral density in humans.
Movérare-Skrtic S, Nilsson KH, Henning P, Funck-Brentano T, Nethander M, Rivadeneira F, Coletto Nunes G, Koskela A, Tuukkanen J, Tuckermann J, Perret C, Souza PPC, Lerner UH, Ohlsson C. Movérare-Skrtic S, et al. Among authors: tuckermann j. FASEB J. 2019 Oct;33(10):11163-11179. doi: 10.1096/fj.201900707R. Epub 2019 Jul 15. FASEB J. 2019. PMID: 31307226 Free PMC article.
., Rivadeneira, F., Coletto Nunes, G., Koskela, A., Tuukkanen, J., Tuckermann, J., Perret, C., Souza, P. P. C., Lerner, U. H., Ohlsson, C. ...
., Rivadeneira, F., Coletto Nunes, G., Koskela, A., Tuukkanen, J., Tuckermann, J., Perret, C., Souza, P. P. C., Lerner, …
Glucocorticoids employ the monomeric glucocorticoid receptor to potentiate vitamin D3 and parathyroid hormone-induced osteoclastogenesis.
Conaway HH, Henning P, Lie A, Tuckermann J, Lerner UH. Conaway HH, et al. Among authors: tuckermann j. FASEB J. 2019 Dec;33(12):14394-14409. doi: 10.1096/fj.201802729RRR. Epub 2019 Nov 14. FASEB J. 2019. PMID: 31675485 Free PMC article.
These data demonstrate that the GR cooperates with D3 and PTH signaling, causing massive osteoclastogenesis, which may explain the rapid bone loss observed with high dosages of GC treatment.-Conaway, H. H., Henning, P., Lie, A., Tuckermann, J., Lerner, U. H. Glucoco …
These data demonstrate that the GR cooperates with D3 and PTH signaling, causing massive osteoclastogenesis, which may explain the rapid bon …
Estradiol and RSPO3 regulate vertebral trabecular bone mass independent of each other.
Nilsson KH, Wu J, Gustafsson KL, El Shahawy M, Koskela A, Tuukkanen J, Tuckermann J, Henning P, Lerner UH, Ohlsson C, Movérare-Skrtic S. Nilsson KH, et al. Among authors: tuckermann j. Am J Physiol Endocrinol Metab. 2022 Mar 1;322(3):E211-E218. doi: 10.1152/ajpendo.00383.2021. Epub 2022 Jan 24. Am J Physiol Endocrinol Metab. 2022. PMID: 35068191 Free PMC article.
Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor.
Rauch A, Seitz S, Baschant U, Schilling AF, Illing A, Stride B, Kirilov M, Mandic V, Takacz A, Schmidt-Ullrich R, Ostermay S, Schinke T, Spanbroek R, Zaiss MM, Angel PE, Lerner UH, David JP, Reichardt HM, Amling M, Schütz G, Tuckermann JP. Rauch A, et al. Cell Metab. 2010 Jun 9;11(6):517-31. doi: 10.1016/j.cmet.2010.05.005. Cell Metab. 2010. PMID: 20519123 Free article.
188 results