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Discovery of N-(4-(3-isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-yl)-4-(4-methylpiperazin-1-yl)quinazolin-7-amine as a Novel, Potent, and Oral Cyclin-Dependent Kinase Inhibitor against Haematological Malignancies.
Huang J, Wang X, Dong R, Liu X, Li H, Zhang T, Xu J, Liu C, Zhang Y, Hou S, Tang W, Lu T, Chen Y. Huang J, et al. Among authors: liu x, liu c. J Med Chem. 2021 Sep 9;64(17):12548-12571. doi: 10.1021/acs.jmedchem.1c00271. Epub 2021 Aug 20. J Med Chem. 2021. PMID: 34415148
Discovery of 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as potent and selective CDK9 inhibitors that enable transient target engagement for the treatment of hematologic malignancies.
Wang X, Liu X, Huang J, Liu C, Li H, Wang C, Hong Q, Lei Y, Xia J, Yu Z, Dong R, Xu J, Tu Z, Duan C, Li S, Lu T, Tang W, Chen Y. Wang X, et al. Among authors: liu x, liu c. Eur J Med Chem. 2022 Aug 5;238:114461. doi: 10.1016/j.ejmech.2022.114461. Epub 2022 May 16. Eur J Med Chem. 2022. PMID: 35605362
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