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Discovery of N-(4-(3-isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-yl)-4-(4-methylpiperazin-1-yl)quinazolin-7-amine as a Novel, Potent, and Oral Cyclin-Dependent Kinase Inhibitor against Haematological Malignancies.
Huang J, Wang X, Dong R, Liu X, Li H, Zhang T, Xu J, Liu C, Zhang Y, Hou S, Tang W, Lu T, Chen Y. Huang J, et al. Among authors: xu j. J Med Chem. 2021 Sep 9;64(17):12548-12571. doi: 10.1021/acs.jmedchem.1c00271. Epub 2021 Aug 20. J Med Chem. 2021. PMID: 34415148
Identification of N-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine Derivatives as Novel, Potent, and Selective NF-κB Inducing Kinase (NIK) Inhibitors for the Treatment of Psoriasis.
Zhu Y, Ma Y, Zu W, Song J, Wang H, Zhong Y, Li H, Zhang Y, Gao Q, Kong B, Xu J, Jiang F, Wang X, Li S, Liu C, Liu H, Lu T, Chen Y. Zhu Y, et al. Among authors: xu j. J Med Chem. 2020 Jul 9;63(13):6748-6773. doi: 10.1021/acs.jmedchem.0c00055. Epub 2020 Jun 16. J Med Chem. 2020. PMID: 32479083
Discovery of 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as potent and selective CDK9 inhibitors that enable transient target engagement for the treatment of hematologic malignancies.
Wang X, Liu X, Huang J, Liu C, Li H, Wang C, Hong Q, Lei Y, Xia J, Yu Z, Dong R, Xu J, Tu Z, Duan C, Li S, Lu T, Tang W, Chen Y. Wang X, et al. Among authors: xu j. Eur J Med Chem. 2022 Aug 5;238:114461. doi: 10.1016/j.ejmech.2022.114461. Epub 2022 May 16. Eur J Med Chem. 2022. PMID: 35605362
Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis.
Jiang F, Hu Q, Zhang Z, Li H, Li H, Zhang D, Li H, Ma Y, Xu J, Chen H, Cui Y, Zhi Y, Zhang Y, Xu J, Zhu J, Lu T, Chen Y. Jiang F, et al. Among authors: xu j. J Med Chem. 2019 Dec 26;62(24):11080-11107. doi: 10.1021/acs.jmedchem.9b01010. Epub 2019 Dec 13. J Med Chem. 2019. PMID: 31789032
Decreased gray matter volume in the anterior cerebellar of attention deficit/hyperactivity disorder comorbid oppositional defiant disorder children with associated cerebellar-cerebral hyperconnectivity: insights from a combined structural MRI and resting-state fMRI study.
Wang X, Guo Y, Xu J, Xiao Y, Fu Y. Wang X, et al. Among authors: xu j. Int J Dev Neurosci. 2024 May 25. doi: 10.1002/jdn.10349. Online ahead of print. Int J Dev Neurosci. 2024. PMID: 38795021
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