Ambrose AJ - Search Results

1

A two-step resin based approach to reveal survivin-selective fluorescent probes.

Ambrose AJ, Pham NT, Sivinski J, Guimarães L, Mollasalehi N, Jimenez P, Abad MA, Jeyaprakash AA, Shave S, Costa-Lotufo LV, La Clair JJ, Auer M, Chapman E. Ambrose AJ, et al. RSC Chem Biol. 2020 Nov 27;2(1):181-186. doi: 10.1039/d0cb00122h. eCollection 2021 Feb 1. RSC Chem Biol. 2020. PMID: 34458780 Free PMC article.

2

Unfolded DapA forms aggregates when diluted into free solution, confounding comparison with folding by the GroEL/GroES chaperonin system.

Ambrose A, Fenton W, Mason DJ, Chapman E, Horwich AL. Ambrose A, et al. FEBS Lett. 2015 Feb 13;589(4):497-499. doi: 10.1016/j.febslet.2015.01.008. Epub 2015 Jan 17. FEBS Lett. 2015. PMID: 25601566 Free PMC article.

3

The Hybrid Pyrroloisoindolone-Dehydropyrrolizine Alkaloid (-)-Chlorizidine A Targets Proteins within the Glycolytic Pathway.

Álvarez-Micó X, Rocha DD, Guimarães LA, Ambrose A, Chapman E, Costa-Lotufo LV, La Clair JJ, Fenical W. Álvarez-Micó X, et al. Chembiochem. 2015 Sep 21;16(14):2002-6. doi: 10.1002/cbic.201500229. Epub 2015 Aug 12. Chembiochem. 2015. PMID: 26267855 Free PMC article.

4

Ritterostatin G_N 1_N , a Cephalostatin-Ritterazine Bis-steroidal Pyrazine Hybrid, Selectively Targets GRP78.

Ambrose AJ, Santos EA, Jimenez PC, Rocha DD, Wilke DV, Beuzer P, Axelrod J, Kumar Kanduluru A, Fuchs PL, Cang H, Costa-Lotufo LV, Chapman E, La Clair JJ. Ambrose AJ, et al. Chembiochem. 2017 Mar 16;18(6):506-510. doi: 10.1002/cbic.201600669. Epub 2017 Feb 2. Chembiochem. 2017. PMID: 28074539 Free PMC article.

5

Arsenic Compromises Both p97 and Proteasome Functions.

Tillotson J, Zerio CJ, Harder B, Ambrose AJ, Jung KS, Kang M, Zhang DD, Chapman E. Tillotson J, et al. Among authors: ambrose aj. Chem Res Toxicol. 2017 Jul 17;30(7):1508-1514. doi: 10.1021/acs.chemrestox.7b00158. Epub 2017 Jul 7. Chem Res Toxicol. 2017. PMID: 28636814 Free PMC article.

6

ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A.

Tillotson J, Kedzior M, Guimarães L, Ross AB, Peters TL, Ambrose AJ, Schmidlin CJ, Zhang DD, Costa-Lotufo LV, Rodríguez AD, Schatz JH, Chapman E. Tillotson J, et al. Among authors: ambrose aj. Bioorg Med Chem Lett. 2017 Sep 1;27(17):4082-4085. doi: 10.1016/j.bmcl.2017.07.045. Epub 2017 Jul 19. Bioorg Med Chem Lett. 2017. PMID: 28757063 Free PMC article.

7

Increased O-GlcNAcylation of SNAP29 Drives Arsenic-Induced Autophagic Dysfunction.

Dodson M, Liu P, Jiang T, Ambrose AJ, Luo G, Rojo de la Vega M, Cholanians AB, Wong PK, Chapman E, Zhang DD. Dodson M, et al. Among authors: ambrose aj. Mol Cell Biol. 2018 May 15;38(11):e00595-17. doi: 10.1128/MCB.00595-17. Print 2018 Jun 1. Mol Cell Biol. 2018. PMID: 29507186 Free PMC article.

8

A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78.

Ambrose AJ, Zerio CJ, Sivinski J, Schmidlin CJ, Shi T, Ross AB, Widrick KJ, Johnson SM, Zhang DD, Chapman E. Ambrose AJ, et al. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1689-1693. doi: 10.1016/j.bmcl.2019.05.041. Epub 2019 May 20. Bioorg Med Chem Lett. 2019. PMID: 31129054 Free PMC article.

9

One-Step Synthesis of Thieno[2,3-d]pyrimidin-4(3H)-ones via a Catalytic Four-Component Reaction of Ketones, Ethyl Cyanoacetate, S₈ and Formamide.

Shi T, Kaneko L, Sandino M, Busse R, Zhang M, Mason D, Machulis J, Ambrose AJ, Zhang DD, Chapman E. Shi T, et al. Among authors: ambrose aj. ACS Sustain Chem Eng. 2019 Jan 7;7(1):1524-1528. doi: 10.1021/acssuschemeng.8b05276. Epub 2018 Dec 14. ACS Sustain Chem Eng. 2019. PMID: 31754553 Free PMC article.

10

A one-step, atom economical synthesis of thieno[2,3-d]pyrimidin-4-amine derivatives via a four-component reaction.

Shi T, Zerio CJ, Sivinski J, Ambrose AJ, Moore KT, Buckley T, Kaneko L, Zhang M, Zhang DD, Chapman E. Shi T, et al. Among authors: ambrose aj. European J Org Chem. 2019 Jun 2;20(2):3269-3272. doi: 10.1002/ejoc.201900414. Epub 2019 Apr 30. European J Org Chem. 2019. PMID: 31857792 Free PMC article.

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