Xiao J - Search Results

1

Development of Multifunctional and Orally Active Cyclic Peptide Agonists of Opioid/Neuropeptide FF Receptors that Produce Potent, Long-Lasting, and Peripherally Restricted Antinociception with Diminished Side Effects.

Zhang M, Xu B, Li N, Zhang R, Zhang Q, Shi X, Xu K, Xiao J, Chen D, Niu J, Shi Y, Fang Q. Zhang M, et al. Among authors: xiao j. J Med Chem. 2021 Sep 23;64(18):13394-13409. doi: 10.1021/acs.jmedchem.1c00694. Epub 2021 Aug 31. J Med Chem. 2021. PMID: 34465090

2

Analgesic activities of the mixed opioid and NPFF receptors agonist DN-9 in a mouse model of formalin-induced orofacial inflammatory pain.

Zhang T, Zhao W, Zhang M, Xu B, Shi X, Zhang Q, Guo Y, Xiao J, Chen D, Zheng T, Fang Q. Zhang T, et al. Among authors: xiao j. Peptides. 2018 Dec;110:30-39. doi: 10.1016/j.peptides.2018.10.010. Epub 2018 Nov 1. Peptides. 2018. PMID: 30391423

3

Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines.

Zhang T, Zhang N, Zhang R, Zhao W, Chen Y, Wang Z, Xu B, Zhang M, Shi X, Zhang Q, Guo Y, Xiao J, Chen D, Fang Q. Zhang T, et al. Among authors: xiao j. J Neuroinflammation. 2018 Nov 15;15(1):320. doi: 10.1186/s12974-018-1358-3. J Neuroinflammation. 2018. PMID: 30442166 Free PMC article.

4

Discovery of two novel branched peptidomimetics containing endomorphin-2 and RF9 pharmacophores: Synthesis and neuropharmacological evaluation.

Zhang T, Han Z, Shi X, Zhao W, Wang Z, Zhang R, Xu B, Zhang M, Zhang Q, Xiao J, Zhu H, Zheng T, Fang Q. Zhang T, et al. Among authors: xiao j. Bioorg Med Chem. 2019 Feb 15;27(4):630-643. doi: 10.1016/j.bmc.2019.01.003. Epub 2019 Jan 4. Bioorg Med Chem. 2019. PMID: 30626554

5

Spinal DN-9, a Peptidic Multifunctional Opioid/Neuropeptide FF Agonist Produced Potent Nontolerance Forming Analgesia With Limited Side Effects.

Wang Z, Xu B, Jiang C, Zhang T, Zhang M, Li N, Zhang Q, Xu K, Chen D, Xiao J, Fang Q. Wang Z, et al. Among authors: xiao j. J Pain. 2020 Mar-Apr;21(3-4):477-493. doi: 10.1016/j.jpain.2019.08.016. Epub 2019 Sep 12. J Pain. 2020. PMID: 31521796 Free article.

6

Central and peripheral modulation of gastrointestinal transit in mice by DN-9, a multifunctional opioid/NPFF receptor agonist.

Xu B, Guo Y, Zhang M, Zhang R, Chen D, Zhang Q, Xiao J, Xu K, Li N, Qiu Y, Zhu H, Niu J, Zhang X, Fang Q. Xu B, et al. Among authors: xiao j. Neurogastroenterol Motil. 2020 Aug;32(8):e13848. doi: 10.1111/nmo.13848. Epub 2020 Apr 12. Neurogastroenterol Motil. 2020. PMID: 32281198

7

Spinal administration of the multi-functional opioid/neuropeptide FF agonist BN-9 produced potent antinociception without development of tolerance and opioid-induced hyperalgesia.

Zhang R, Xu B, Zhang Q, Chen D, Zhang M, Zhao G, Xu K, Xiao J, Zhu H, Niu J, Li N, Fang Q. Zhang R, et al. Among authors: xiao j. Eur J Pharmacol. 2020 Aug 5;880:173169. doi: 10.1016/j.ejphar.2020.173169. Epub 2020 May 13. Eur J Pharmacol. 2020. PMID: 32416184

8

VF-13, a chimeric peptide of VD-hemopressin(α) and neuropeptide VF, produces potent antinociception with reduced cannabinoid-related side effects.

Xu B, Xiao J, Xu K, Zhang Q, Chen D, Zhang R, Zhang M, Zhu H, Niu J, Zheng T, Li N, Zhang X, Fang Q. Xu B, et al. Among authors: xiao j. Neuropharmacology. 2020 Sep 15;175:108178. doi: 10.1016/j.neuropharm.2020.108178. Epub 2020 Jun 13. Neuropharmacology. 2020. PMID: 32544481

9

Synthesis and Biological Characterization of Cyclic Disulfide-Containing Peptide Analogs of the Multifunctional Opioid/Neuropeptide FF Receptor Agonists That Produce Long-Lasting and Nontolerant Antinociception.

Zhang M, Xu B, Li N, Liu H, Shi X, Zhang Q, Shi Y, Xu K, Xiao J, Chen D, Zhu H, Sun Y, Zhang T, Zhang R, Fang Q. Zhang M, et al. Among authors: xiao j. J Med Chem. 2020 Dec 24;63(24):15709-15725. doi: 10.1021/acs.jmedchem.0c01367. Epub 2020 Dec 3. J Med Chem. 2020. PMID: 33271020

10

Spinal endomorphins attenuate burn-injury pain in male mice by inhibiting p38 MAPK signaling pathway through the mu-opioid receptor.

Zhang T, Zhang R, Xu B, Zhang M, Zhang Q, Li N, Qiu Y, Chen D, Xu K, Xiao J, Zhang N, Fang Q. Zhang T, et al. Among authors: xiao j. Eur J Pharmacol. 2021 Jul 15;903:174139. doi: 10.1016/j.ejphar.2021.174139. Epub 2021 Apr 30. Eur J Pharmacol. 2021. PMID: 33933465

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