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Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer.
Lin J, Liu H, Fukumoto T, Zundell J, Yan Q, Tang CA, Wu S, Zhou W, Guo D, Karakashev S, Hu CA, Sarma K, Kossenkov AV, Zhang R. Lin J, et al. Among authors: tang ca. Nat Commun. 2021 Sep 7;12(1):5321. doi: 10.1038/s41467-021-25684-3. Nat Commun. 2021. PMID: 34493732 Free PMC article.
STING regulates BCR signaling in normal and malignant B cells.
Tang CA, Lee AC, Chang S, Xu Q, Shao A, Lo Y, Spalek WT, Pinilla-Ibarz JA, Del Valle JR, Hu CA. Tang CA, et al. Cell Mol Immunol. 2021 Apr;18(4):1016-1031. doi: 10.1038/s41423-020-00552-0. Epub 2020 Sep 30. Cell Mol Immunol. 2021. PMID: 32999453 Free PMC article.
Development of Tumor-Targeting IRE-1 Inhibitors for B-cell Cancer Therapy.
Shao A, Xu Q, Spalek WT, Cain CF, Kang CW, Tang CA, Del Valle JR, Hu CA. Shao A, et al. Among authors: tang ca. Mol Cancer Ther. 2020 Dec;19(12):2432-2444. doi: 10.1158/1535-7163.MCT-20-0127. Epub 2020 Oct 13. Mol Cancer Ther. 2020. PMID: 33051362 Free PMC article.
An interdomain helix in IRE1α mediates the conformational change required for the sensor's activation.
Ricci D, Tutton S, Marrocco I, Ying M, Blumenthal D, Eletto D, Vargas J, Boyle S, Fazelinia H, Qian L, Suresh K, Taylor D, Paton JC, Paton AW, Tang CA, Hu CA, Radhakrishnan R, Gidalevitz T, Argon Y. Ricci D, et al. Among authors: tang ca. J Biol Chem. 2021 Jan-Jun;296:100781. doi: 10.1016/j.jbc.2021.100781. Epub 2021 May 14. J Biol Chem. 2021. PMID: 34000298 Free PMC article.
Distinct mechanisms govern populations of myeloid-derived suppressor cells in chronic viral infection and cancer.
Tcyganov EN, Hanabuchi S, Hashimoto A, Campbell D, Kar G, Slidel TW, Cayatte C, Landry A, Pilataxi F, Hayes S, Dougherty B, Hicks KC, Mulgrew K, Tang CA, Hu CA, Guo W, Grivennikov S, Ali MA, Beltra JC, Wherry EJ, Nefedova Y, Gabrilovich DI. Tcyganov EN, et al. Among authors: tang ca. J Clin Invest. 2021 Aug 16;131(16):e145971. doi: 10.1172/JCI145971. J Clin Invest. 2021. PMID: 34228641 Free PMC article.
19 results