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Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides.
Helton LG, Soliman A, von Zweydorf F, Kentros M, Manschwetus JT, Hall S, Gilsbach B, Ho FY, Athanasopoulos PS, Singh RK, LeClair TJ, Versées W, Raimondi F, Herberg FW, Gloeckner CJ, Rideout H, Kortholt A, Kennedy EJ. Helton LG, et al. Among authors: rideout h. ACS Chem Biol. 2021 Nov 19;16(11):2326-2338. doi: 10.1021/acschembio.1c00487. Epub 2021 Sep 8. ACS Chem Biol. 2021. PMID: 34496561 Free article.
Editorial: LRRK2-Fifteen Years From Cloning to the Clinic.
Rideout H, Greggio E, Kortholt A, Nichols RJ. Rideout H, et al. Front Neurosci. 2022 Apr 11;16:880914. doi: 10.3389/fnins.2022.880914. eCollection 2022. Front Neurosci. 2022. PMID: 35478845 Free PMC article. No abstract available.
LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson's disease.
Kedariti M, Frattini E, Baden P, Cogo S, Civiero L, Ziviani E, Zilio G, Bertoli F, Aureli M, Kaganovich A, Cookson MR, Stefanis L, Surface M, Deleidi M, Di Fonzo A, Alcalay RN, Rideout H, Greggio E, Plotegher N. Kedariti M, et al. Among authors: rideout h. NPJ Parkinsons Dis. 2022 Jul 19;8(1):92. doi: 10.1038/s41531-022-00354-3. NPJ Parkinsons Dis. 2022. PMID: 35853899 Free PMC article.
Vitamin B12 modulates Parkinson's disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection.
Schaffner A, Li X, Gomez-Llorente Y, Leandrou E, Memou A, Clemente N, Yao C, Afsari F, Zhi L, Pan N, Morohashi K, Hua X, Zhou MM, Wang C, Zhang H, Chen SG, Elliott CJ, Rideout H, Ubarretxena-Belandia I, Yue Z. Schaffner A, et al. Among authors: rideout h. Cell Res. 2019 Apr;29(4):313-329. doi: 10.1038/s41422-019-0153-8. Epub 2019 Mar 11. Cell Res. 2019. PMID: 30858560 Free PMC article.
57 results