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Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides.
Helton LG, Soliman A, von Zweydorf F, Kentros M, Manschwetus JT, Hall S, Gilsbach B, Ho FY, Athanasopoulos PS, Singh RK, LeClair TJ, Versées W, Raimondi F, Herberg FW, Gloeckner CJ, Rideout H, Kortholt A, Kennedy EJ. Helton LG, et al. Among authors: singh rk. ACS Chem Biol. 2021 Nov 19;16(11):2326-2338. doi: 10.1021/acschembio.1c00487. Epub 2021 Sep 8. ACS Chem Biol. 2021. PMID: 34496561 Free article.
Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2.
Singh RK, Soliman A, Guaitoli G, Störmer E, von Zweydorf F, Dal Maso T, Oun A, Van Rillaer L, Schmidt SH, Chatterjee D, David JA, Pardon E, Schwartz TU, Knapp S, Kennedy EJ, Steyaert J, Herberg FW, Kortholt A, Gloeckner CJ, Versées W. Singh RK, et al. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2112712119. doi: 10.1073/pnas.2112712119. Proc Natl Acad Sci U S A. 2022. PMID: 35217606 Free PMC article.
Entropic pressure controls the oligomerization of the Vibrio cholerae ParD2 antitoxin.
Garcia-Rodriguez G, Girardin Y, Volkov AN, Singh RK, Muruganandam G, Van Dyck J, Sobott F, Versées W, Charlier D, Loris R. Garcia-Rodriguez G, et al. Among authors: singh rk. Acta Crystallogr D Struct Biol. 2021 Jul 1;77(Pt 7):904-920. doi: 10.1107/S2059798321004873. Epub 2021 Jun 18. Acta Crystallogr D Struct Biol. 2021. PMID: 34196617 Free PMC article.
Biochemical determinants of ObgE-mediated persistence.
Verstraeten N, Gkekas S, Kint CI, Deckers B, Van den Bergh B, Herpels P, Louwagie E, Knapen W, Wilmaerts D, Dewachter L, Fauvart M, Singh RK, Michiels J, Versées W. Verstraeten N, et al. Among authors: singh rk. Mol Microbiol. 2019 Nov;112(5):1593-1608. doi: 10.1111/mmi.14382. Epub 2019 Sep 18. Mol Microbiol. 2019. PMID: 31498933 Free article.
Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors.
Talavera A, Hendrix J, Versées W, Jurėnas D, Van Nerom K, Vandenberk N, Singh RK, Konijnenberg A, De Gieter S, Castro-Roa D, Barth A, De Greve H, Sobott F, Hofkens J, Zenkin N, Loris R, Garcia-Pino A. Talavera A, et al. Among authors: singh rk. Sci Adv. 2018 Mar 14;4(3):eaap9714. doi: 10.1126/sciadv.aap9714. eCollection 2018 Mar. Sci Adv. 2018. PMID: 29546243 Free PMC article.
2,710 results