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Elevating CDCA3 Levels Enhances Tyrosine Kinase Inhibitor Sensitivity in TKI-Resistant EGFR Mutant Non-Small-Cell Lung Cancer.
Sahin KB, Shah ET, Ferguson GP, Molloy C, Kalita-de Croft P, Hayes SA, Hudson A, Colvin E, Kamitakahara H, Harvie R, Hasovits C, Khan T, Duijf PHG, Howell VM, He Y, Bolderson E, Hooper JD, Lakhani SR, Richard DJ, O'Byrne KJ, Adams MN. Sahin KB, et al. Among authors: hooper jd. Cancers (Basel). 2021 Sep 16;13(18):4651. doi: 10.3390/cancers13184651. Cancers (Basel). 2021. PMID: 34572879 Free PMC article.
Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCdelta.
He Y, Wortmann A, Burke LJ, Reid JC, Adams MN, Abdul-Jabbar I, Quigley JP, Leduc R, Kirchhofer D, Hooper JD. He Y, et al. Among authors: hooper jd. J Biol Chem. 2010 Aug 20;285(34):26162-73. doi: 10.1074/jbc.M109.096453. Epub 2010 Jun 15. J Biol Chem. 2010. PMID: 20551327 Free PMC article.
Structure, function and pathophysiology of protease activated receptors.
Adams MN, Ramachandran R, Yau MK, Suen JY, Fairlie DP, Hollenberg MD, Hooper JD. Adams MN, et al. Among authors: hooper jd. Pharmacol Ther. 2011 Jun;130(3):248-82. doi: 10.1016/j.pharmthera.2011.01.003. Epub 2011 Jan 26. Pharmacol Ther. 2011. PMID: 21277892 Review.
EGF inhibits constitutive internalization and palmitoylation-dependent degradation of membrane-spanning procancer CDCP1 promoting its availability on the cell surface.
Adams MN, Harrington BS, He Y, Davies CM, Wallace SJ, Chetty NP, Crandon AJ, Oliveira NB, Shannon CM, Coward JI, Lumley JW, Perrin LC, Armes JE, Hooper JD. Adams MN, et al. Among authors: hooper jd. Oncogene. 2015 Mar 12;34(11):1375-83. doi: 10.1038/onc.2014.88. Epub 2014 Mar 31. Oncogene. 2015. PMID: 24681947
Potent Small Agonists of Protease Activated Receptor 2.
Yau MK, Suen JY, Xu W, Lim J, Liu L, Adams MN, He Y, Hooper JD, Reid RC, Fairlie DP. Yau MK, et al. Among authors: hooper jd. ACS Med Chem Lett. 2015 Nov 30;7(1):105-10. doi: 10.1021/acsmedchemlett.5b00429. eCollection 2016 Jan 14. ACS Med Chem Lett. 2015. PMID: 26819675 Free PMC article.
124 results