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Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2.
van de Wetering C, Manuel AM, Sharafi M, Aboushousha R, Qian X, Erickson C, MacPherson M, Chan G, Adcock IM, ZounematKermani N, Schleich F, Louis R, Bohrnsen E, D'Alessandro A, Wouters EF, Reynaert NL, Li J, Wolf CR, Henderson CJ, Lundblad LKA, Poynter ME, Dixon AE, Irvin CG, van der Vliet A, van der Velden JL, Janssen-Heininger YM. van de Wetering C, et al. Among authors: macpherson m. Redox Biol. 2021 Nov;47:102160. doi: 10.1016/j.redox.2021.102160. Epub 2021 Oct 3. Redox Biol. 2021. PMID: 34624602 Free PMC article.
Pyruvate Kinase M2 Promotes Expression of Proinflammatory Mediators in House Dust Mite-Induced Allergic Airways Disease.
van de Wetering C, Aboushousha R, Manuel AM, Chia SB, Erickson C, MacPherson MB, van der Velden JL, Anathy V, Dixon AE, Irvin CG, Poynter ME, van der Vliet A, Wouters EFM, Reynaert NL, Janssen-Heininger YMW. van de Wetering C, et al. Among authors: macpherson mb. J Immunol. 2020 Feb 15;204(4):763-774. doi: 10.4049/jimmunol.1901086. Epub 2020 Jan 10. J Immunol. 2020. PMID: 31924651 Free PMC article.
Dysregulation of Pyruvate Kinase M2 Promotes Inflammation in a Mouse Model of Obese Allergic Asthma.
Manuel AM, van de Wetering C, MacPherson M, Erickson C, Murray C, Aboushousha R, van der Velden J, Dixon AE, Poynter ME, Irvin CG, Taatjes DJ, van der Vliet A, Anathy V, Janssen-Heininger YMW. Manuel AM, et al. Among authors: macpherson m. Am J Respir Cell Mol Biol. 2021 Jun;64(6):709-721. doi: 10.1165/rcmb.2020-0512OC. Am J Respir Cell Mol Biol. 2021. PMID: 33662229 Free PMC article.
Glutathionylation chemistry promotes interleukin-1 beta-mediated glycolytic reprogramming and pro-inflammatory signaling in lung epithelial cells.
Aboushousha R, Elko E, Chia SB, Manuel AM, van de Wetering C, van der Velden J, MacPherson M, Erickson C, Reisz JA, D'Alessandro A, Wouters EFM, Reynaert NL, Lam YW, Anathy V, van der Vliet A, Seward DJ, Janssen-Heininger YMW. Aboushousha R, et al. Among authors: macpherson m. FASEB J. 2021 May;35(5):e21525. doi: 10.1096/fj.202002687RR. FASEB J. 2021. PMID: 33817836 Free PMC article.
Structural and functional fine mapping of cysteines in mammalian glutaredoxin reveal their differential oxidation susceptibility.
Corteselli EM, Sharafi M, Hondal R, MacPherson M, White S, Lam YW, Gold C, Manuel AM, van der Vliet A, Schneebeli ST, Anathy V, Li J, Janssen-Heininger YMW. Corteselli EM, et al. Among authors: macpherson m. Nat Commun. 2023 Jul 28;14(1):4550. doi: 10.1038/s41467-023-39664-2. Nat Commun. 2023. PMID: 37507364 Free PMC article.
Glutaredoxin attenuates glutathione levels via deglutathionylation of Otub1 and subsequent destabilization of system xC.
Aboushousha R, van der Velden J, Hamilton N, Peng Z, MacPherson M, Erickson C, White S, Wouters EFM, Reynaert NL, Seward DJ, Li J, Janssen-Heininger YMW. Aboushousha R, et al. Among authors: macpherson m. Sci Adv. 2023 Sep 15;9(37):eadi5192. doi: 10.1126/sciadv.adi5192. Epub 2023 Sep 13. Sci Adv. 2023. PMID: 37703360 Free PMC article.
Microspheres targeted with a mesothelin antibody and loaded with doxorubicin reduce tumor volume of human mesotheliomas in xenografts.
Macura SL, Steinbacher JL, Macpherson MB, Lathrop MJ, Sayan M, Hillegass JM, Beuschel SL, Perkins TN, Spiess PC, van der Vliet A, Butnor KJ, Shukla A, Wadsworth M, Landry CC, Mossman BT. Macura SL, et al. Among authors: macpherson mb. BMC Cancer. 2013 Sep 11;13:400. doi: 10.1186/1471-2407-13-400. BMC Cancer. 2013. PMID: 24024776 Free PMC article.
290 results