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Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence.
Li Y, Kračun D, Dustin CM, El Massry M, Yuan S, Goossen CJ, DeVallance ER, Sahoo S, St Hilaire C, Gurkar AU, Finkel T, Straub AC, Cifuentes-Pagano E, Pagano PJ. Li Y, et al. Among authors: gurkar au. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2015666118. doi: 10.1073/pnas.2015666118. Proc Natl Acad Sci U S A. 2021. PMID: 34654740 Free PMC article.
Synergistic treatment of TS.
Gurkar AU, Finkel T. Gurkar AU, et al. Oncotarget. 2017 Aug 8;8(39):64653-64654. doi: 10.18632/oncotarget.20024. eCollection 2017 Sep 12. Oncotarget. 2017. PMID: 29027545 Free PMC article. No abstract available.
Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging.
Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RAS, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti LH, Opresko PL, Stolz DB, Watkins SC, Burd CE, Croix CMS, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelley EE, Niedernhofer LJ. Robinson AR, et al. Among authors: gurkar au. Redox Biol. 2018 Jul;17:259-273. doi: 10.1016/j.redox.2018.04.007. Epub 2018 Apr 13. Redox Biol. 2018. PMID: 29747066 Free PMC article.
Lipids as Regulators of Cellular Senescence.
Hamsanathan S, Gurkar AU. Hamsanathan S, et al. Among authors: gurkar au. Front Physiol. 2022 Mar 4;13:796850. doi: 10.3389/fphys.2022.796850. eCollection 2022. Front Physiol. 2022. PMID: 35370799 Free PMC article. Review.
Quantitative Analysis of Cellular Senescence in Culture and In Vivo.
Zhao J, Fuhrmann-Stroissnigg H, Gurkar AU, Flores RR, Dorronsoro A, Stolz DB, St Croix CM, Niedernhofer LJ, Robbins PD. Zhao J, et al. Among authors: gurkar au. Curr Protoc Cytom. 2017 Jan 5;79:9.51.1-9.51.25. doi: 10.1002/cpcy.16. Curr Protoc Cytom. 2017. PMID: 28055114
ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging.
Zhao J, Zhang L, Lu A, Han Y, Colangelo D, Bukata C, Scibetta A, Yousefzadeh MJ, Li X, Gurkar AU, McGowan SJ, Angelini L, O'Kelly R, Li H, Corbo L, Sano T, Nick H, Pola E, Pilla SPS, Ladiges WC, Vo N, Huard J, Niedernhofer LJ, Robbins PD. Zhao J, et al. Among authors: gurkar au. Aging (Albany NY). 2020 Mar 22;12(6):4688-4710. doi: 10.18632/aging.102863. Epub 2020 Mar 22. Aging (Albany NY). 2020. PMID: 32201398 Free PMC article.
Frataxin deficiency promotes endothelial senescence in pulmonary hypertension.
Culley MK, Zhao J, Tai YY, Tang Y, Perk D, Negi V, Yu Q, Woodcock CC, Handen A, Speyer G, Kim S, Lai YC, Satoh T, Watson AM, Aaraj YA, Sembrat J, Rojas M, Goncharov D, Goncharova EA, Khan OF, Anderson DG, Dahlman JE, Gurkar AU, Lafyatis R, Fayyaz AU, Redfield MM, Gladwin MT, Rabinovitch M, Gu M, Bertero T, Chan SY. Culley MK, et al. Among authors: gurkar au. J Clin Invest. 2021 Jun 1;131(11):e136459. doi: 10.1172/JCI136459. J Clin Invest. 2021. PMID: 33905372 Free PMC article.
32 results