George S - Search Results

1

Borcalein: a Carborane-Based Analogue of Baicalein with 12-Lipoxygenase-Independent Toxicity.

Kuhnert R, Kuhnert L, Sárosi MB, George S, Draca D, Paskas S, Hofmann B, Steinhilber D, Honscha W, Mijatović S, Maksimović-Ivanić D, Hey-Hawkins E. Kuhnert R, et al. Among authors: george s. ChemMedChem. 2022 Jan 5;17(1):e202100588. doi: 10.1002/cmdc.202100588. Epub 2021 Nov 11. ChemMedChem. 2022. PMID: 34694057 Free PMC article.

2

Design and synthesis of novel 2-amino-5-hydroxyindole derivatives that inhibit human 5-lipoxygenase.

Landwehr J, George S, Karg EM, Poeckel D, Steinhilber D, Troschuetz R, Werz O. Landwehr J, et al. Among authors: george s. J Med Chem. 2006 Jul 13;49(14):4327-32. doi: 10.1021/jm050801i. J Med Chem. 2006. PMID: 16821792

3

Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening.

Franke L, Schwarz O, Müller-Kuhrt L, Hoernig C, Fischer L, George S, Tanrikulu Y, Schneider P, Werz O, Steinhilber D, Schneider G. Franke L, et al. Among authors: george s. J Med Chem. 2007 May 31;50(11):2640-6. doi: 10.1021/jm060655w. Epub 2007 Apr 27. J Med Chem. 2007. PMID: 17461565

4

Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid.

Werz O, Greiner C, Koeberle A, Hoernig C, George S, Popescu L, Syha I, Schubert-Zsilavecz M, Steinhilber D. Werz O, et al. Among authors: george s. J Med Chem. 2008 Sep 11;51(17):5449-53. doi: 10.1021/jm800588x. Epub 2008 Aug 19. J Med Chem. 2008. PMID: 18710209

5

Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations.

Steinbrink SD, Pergola C, Bühring U, George S, Metzner J, Fischer AS, Häfner AK, Wisniewska JM, Geisslinger G, Werz O, Steinhilber D, Maier TJ. Steinbrink SD, et al. Among authors: george s. Cell Mol Life Sci. 2010 Mar;67(5):797-806. doi: 10.1007/s00018-009-0206-0. Epub 2009 Nov 29. Cell Mol Life Sci. 2010. PMID: 20091083 Free PMC article.

6

Inhibition of 5-lipoxygenase by U73122 is due to covalent binding to cysteine 416.

Hörnig M, Markoutsa S, Häfner AK, George S, Wisniewska JM, Rödl CB, Hofmann B, Maier T, Karas M, Werz O, Steinhilber D. Hörnig M, et al. Among authors: george s. Biochim Biophys Acta. 2012 Feb;1821(2):279-86. doi: 10.1016/j.bbalip.2011.11.001. Epub 2011 Nov 23. Biochim Biophys Acta. 2012. PMID: 22137889

7

Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase.

Meirer K, Rödl CB, Wisniewska JM, George S, Häfner AK, Buscató EL, Klingler FM, Hahn S, Berressem D, Wittmann SK, Steinhilber D, Hofmann B, Proschak E. Meirer K, et al. Among authors: george s. J Med Chem. 2013 Feb 28;56(4):1777-81. doi: 10.1021/jm301617j. Epub 2013 Feb 7. J Med Chem. 2013. PMID: 23356879

8

Characterization of the interaction of human 5-lipoxygenase with its activating protein FLAP.

Häfner AK, Gerstmeier J, Hörnig M, George S, Ball AK, Schröder M, Garscha U, Werz O, Steinhilber D. Häfner AK, et al. Among authors: george s. Biochim Biophys Acta. 2015 Nov;1851(11):1465-72. doi: 10.1016/j.bbalip.2015.08.010. Epub 2015 Aug 29. Biochim Biophys Acta. 2015. PMID: 26327594

9

CarbORev-5901: The First Carborane-Based Inhibitor of the 5-Lipoxygenase Pathway.

Kuhnert R, Sárosi MB, George S, Lönnecke P, Hofmann B, Steinhilber D, Murganic B, Mijatovic S, Maksimovic-Ivanic D, Hey-Hawkins E. Kuhnert R, et al. Among authors: george s. ChemMedChem. 2017 Jul 6;12(13):1081-1086. doi: 10.1002/cmdc.201700309. Epub 2017 Jun 21. ChemMedChem. 2017. PMID: 28569429

10

Carborane-Based Analogues of 5-Lipoxygenase Inhibitors Co-inhibit Heat Shock Protein 90 in HCT116 Cells.

Kuhnert R, Sárosi MB, George S, Lönnecke P, Hofmann B, Steinhilber D, Steinmann S, Schneider-Stock R, Murganić B, Mijatović S, Maksimović-Ivanić D, Hey-Hawkins E. Kuhnert R, et al. Among authors: george s. ChemMedChem. 2019 Jan 22;14(2):255-261. doi: 10.1002/cmdc.201800651. Epub 2018 Dec 21. ChemMedChem. 2019. PMID: 30471171

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