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The purification, crystallization and preliminary structural characterization of glucose-1-phosphate thymidylyltransferase (RmlA), the first enzyme of the dTDP-L-rhamnose synthesis pathway from Pseudomonas aeruginosa.
Blankenfeldt W, Giraud MF, Leonard G, Rahim R, Creuzenet C, Lam JS, Naismith JH. Blankenfeldt W, et al. Among authors: naismith jh. Acta Crystallogr D Biol Crystallogr. 2000 Nov;56(Pt 11):1501-4. doi: 10.1107/s0907444900010040. Acta Crystallogr D Biol Crystallogr. 2000. PMID: 11053865
Mechanism of the Class I KDPG aldolase.
Fullerton SW, Griffiths JS, Merkel AB, Cheriyan M, Wymer NJ, Hutchins MJ, Fierke CA, Toone EJ, Naismith JH. Fullerton SW, et al. Among authors: naismith jh. Bioorg Med Chem. 2006 May 1;14(9):3002-10. doi: 10.1016/j.bmc.2005.12.022. Epub 2006 Jan 5. Bioorg Med Chem. 2006. PMID: 16403639 Free PMC article.
Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.
Alphey MS, Pirrie L, Torrie LS, Boulkeroua WA, Gardiner M, Sarkar A, Maringer M, Oehlmann W, Brenk R, Scherman MS, McNeil M, Rejzek M, Field RA, Singh M, Gray D, Westwood NJ, Naismith JH. Alphey MS, et al. Among authors: naismith jh. ACS Chem Biol. 2013 Feb 15;8(2):387-96. doi: 10.1021/cb300426u. Epub 2012 Nov 28. ACS Chem Biol. 2013. PMID: 23138692 Free article.
The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery.
Moynie L, Schnell R, McMahon SA, Sandalova T, Boulkerou WA, Schmidberger JW, Alphey M, Cukier C, Duthie F, Kopec J, Liu H, Jacewicz A, Hunter WN, Naismith JH, Schneider G. Moynie L, et al. Among authors: naismith jh. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jan 1;69(Pt 1):25-34. doi: 10.1107/S1744309112044739. Epub 2012 Dec 25. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013. PMID: 23295481 Free PMC article.
Derivatisable Cyanobactin Analogues: A Semisynthetic Approach.
Oueis E, Adamson C, Mann G, Ludewig H, Redpath P, Migaud M, Westwood NJ, Naismith JH. Oueis E, et al. Among authors: naismith jh. Chembiochem. 2015 Dec;16(18):2646-50. doi: 10.1002/cbic.201500494. Epub 2015 Nov 10. Chembiochem. 2015. PMID: 26507241 Free PMC article.
274 results