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The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility.
Spliid CB, Toledo AG, Sanderson P, Mao Y, Gatto F, Gustavsson T, Choudhary S, Saldanha AL, Vogelsang RP, Gögenur I, Theander TG, Leach FE 3rd, Amster IJ, Esko JD, Salanti A, Clausen TM. Spliid CB, et al. Among authors: toledo ag. J Biol Chem. 2021 Dec;297(6):101391. doi: 10.1016/j.jbc.2021.101391. Epub 2021 Nov 8. J Biol Chem. 2021. PMID: 34762909 Free PMC article.
ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis.
Weiss RJ, Spahn PN, Toledo AG, Chiang AWT, Kellman BP, Li J, Benner C, Glass CK, Gordts PLSM, Lewis NE, Esko JD. Weiss RJ, et al. Among authors: toledo ag. Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9311-9317. doi: 10.1073/pnas.1920880117. Epub 2020 Apr 10. Proc Natl Acad Sci U S A. 2020. PMID: 32277030 Free PMC article.
An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.
Toledo AG, Pihl J, Spliid CB, Persson A, Nilsson J, Pereira MA, Gustavsson T, Choudhary S, Oo HZ, Black PC, Daugaard M, Esko JD, Larson G, Salanti A, Clausen TM. Toledo AG, et al. Glycobiology. 2020 Dec 9;30(12):989-1002. doi: 10.1093/glycob/cwaa039. Glycobiology. 2020. PMID: 32337544 Free PMC article.
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