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Benzo[a]pyrene (BaP) metabolites predominant in human plasma following escalating oral micro-dosing with [14C]-BaP.
Vermillion Maier ML, Siddens LK, Pennington JM, Uesugi SL, Anderson KA, Tidwell LG, Tilton SC, Ognibene TJ, Turteltaub KW, Smith JN, Williams DE. Vermillion Maier ML, et al. Among authors: williams de. Environ Int. 2022 Jan 15;159:107045. doi: 10.1016/j.envint.2021.107045. Epub 2021 Dec 15. Environ Int. 2022. PMID: 34920278 Free PMC article.
Pharmacokinetics of [14C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction.
Hummel JM, Madeen EP, Siddens LK, Uesugi SL, McQuistan T, Anderson KA, Turteltaub KW, Ognibene TJ, Bench G, Krueger SK, Harris S, Smith J, Tilton SC, Baird WM, Williams DE. Hummel JM, et al. Among authors: williams de. Food Chem Toxicol. 2018 May;115:136-147. doi: 10.1016/j.fct.2018.03.003. Epub 2018 Mar 5. Food Chem Toxicol. 2018. PMID: 29518434 Free PMC article.
Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing.
Madeen E, Siddens LK, Uesugi S, McQuistan T, Corley RA, Smith J, Waters KM, Tilton SC, Anderson KA, Ognibene T, Turteltaub K, Williams DE. Madeen E, et al. Among authors: williams de. Toxicol Appl Pharmacol. 2019 Feb 1;364:97-105. doi: 10.1016/j.taap.2018.12.010. Epub 2018 Dec 21. Toxicol Appl Pharmacol. 2019. PMID: 30582946 Free PMC article.
3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans.
Vermillion Maier ML, Siddens LK, Uesugi SL, Choi J, Leonard SW, Pennington JM, Tilton SC, Smith JN, Ho E, Chow HHS, Nguyen BD, Kolluri SK, Williams DE. Vermillion Maier ML, et al. Among authors: williams de. Drug Metab Dispos. 2021 Aug;49(8):694-705. doi: 10.1124/dmd.120.000346. Epub 2021 May 25. Drug Metab Dispos. 2021. PMID: 34035125 Free PMC article.
Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse.
Siddens LK, Larkin A, Krueger SK, Bradfield CA, Waters KM, Tilton SC, Pereira CB, Löhr CV, Arlt VM, Phillips DH, Williams DE, Baird WM. Siddens LK, et al. Among authors: williams de. Toxicol Appl Pharmacol. 2012 Nov 1;264(3):377-86. doi: 10.1016/j.taap.2012.08.014. Epub 2012 Aug 23. Toxicol Appl Pharmacol. 2012. PMID: 22935520 Free PMC article.
Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse.
Siddens LK, Bunde KL, Harper TA Jr, McQuistan TJ, Löhr CV, Bramer LM, Waters KM, Tilton SC, Krueger SK, Williams DE, Baird WM. Siddens LK, et al. Among authors: williams de. Toxicol Appl Pharmacol. 2015 Sep 1;287(2):149-160. doi: 10.1016/j.taap.2015.05.019. Epub 2015 Jun 3. Toxicol Appl Pharmacol. 2015. PMID: 26049101 Free PMC article.
Human Microdosing with Carcinogenic Polycyclic Aromatic Hydrocarbons: In Vivo Pharmacokinetics of Dibenzo[def,p]chrysene and Metabolites by UPLC Accelerator Mass Spectrometry.
Madeen EP, Ognibene TJ, Corley RA, McQuistan TJ, Henderson MC, Baird WM, Bench G, Turteltaub KW, Williams DE. Madeen EP, et al. Among authors: williams de. Chem Res Toxicol. 2016 Oct 17;29(10):1641-1650. doi: 10.1021/acs.chemrestox.6b00169. Epub 2016 Sep 9. Chem Res Toxicol. 2016. PMID: 27494294 Free PMC article.
931 results