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FSHR antagonists can trigger a PCOS-like state.
Syst Biol Reprod Med. 2022 Apr;68(2):129-137. doi: 10.1080/19396368.2021.2010837. Epub 2021 Dec 30.
Syst Biol Reprod Med. 2022.
PMID: 34967272
Identification and in vivo validation of a 9-mer peptide derived from FSHβ with FSHR antagonist activity.
Prabhudesai KS, Raje S, Dhamanaskar A, Modi D, Dighe V, Contini A, Idicula-Thomas S.
Prabhudesai KS, et al.
Peptides. 2020 Oct;132:170367. doi: 10.1016/j.peptides.2020.170367. Epub 2020 Jul 6.
Peptides. 2020.
PMID: 32645381
Free article.
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Central residues of FSHβ (89-97) peptide are not critical for FSHR binding: Implications for peptidomimetic design.
Prabhudesai KS, Raje S, Desai K, Modi D, Dighe V, Contini A, Idicula-Thomas S.
Prabhudesai KS, et al.
Bioorg Med Chem Lett. 2021 Jul 15;44:128132. doi: 10.1016/j.bmcl.2021.128132. Epub 2021 May 20.
Bioorg Med Chem Lett. 2021.
PMID: 34022413
Free article.
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A 5-mer peptide derived from hinge region of hFSHR can function as positive allosteric modulator in vivo.
Prabhudesai KS, Aathi MS, Dighe V, Idicula-Thomas S.
Prabhudesai KS, et al.
Biochim Biophys Acta Biomembr. 2021 Jan 1;1863(1):183492. doi: 10.1016/j.bbamem.2020.183492. Epub 2020 Oct 13.
Biochim Biophys Acta Biomembr. 2021.
PMID: 33065137
Free article.
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Mapping of FSHR agonists and antagonists binding sites to identify potential peptidomimetic modulators.
Aathi MS, Kumar C, Prabhudesai KS, Shanmugarajan D, Idicula-Thomas S.
Aathi MS, et al. Among authors: prabhudesai ks.
Biochim Biophys Acta Biomembr. 2022 Apr 1;1864(4):183842. doi: 10.1016/j.bbamem.2021.183842. Epub 2021 Dec 24.
Biochim Biophys Acta Biomembr. 2022.
PMID: 34954201
Free article.
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Discovery of small molecule binders of human FSHR(TMD) with novel structural scaffolds by integrating structural bioinformatics and machine learning algorithms.
Sahu B, Shah S, Prabhudesai K, Contini A, Idicula-Thomas S.
Sahu B, et al.
J Mol Graph Model. 2019 Jun;89:156-166. doi: 10.1016/j.jmgm.2019.02.001. Epub 2019 Mar 5.
J Mol Graph Model. 2019.
PMID: 30897497
Free article.
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A systems biology-based mathematical model demonstrates the potential anti-stress effectiveness of a multi-nutrient botanical formulation.
Saxena A, Prabhudesai KS, Damle A, Ramakrishnan S, Durairaj P, Kalankariyan S, Vijayalakshmi AB, Venkatesh KV.
Saxena A, et al. Among authors: prabhudesai ks.
Sci Rep. 2024 Apr 26;14(1):9582. doi: 10.1038/s41598-024-60112-8.
Sci Rep. 2024.
PMID: 38671040
Free PMC article.
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