Ziegler R - Search Results

1

Secreted acid sphingomyelinase as a potential gene therapy for limb girdle muscular dystrophy 2B.

Bittel DC, Sreetama SC, Chandra G, Ziegler R, Nagaraju K, Van der Meulen JH, Jaiswal JK. Bittel DC, et al. Among authors: ziegler r. J Clin Invest. 2022 Jan 4;132(1):e141295. doi: 10.1172/JCI141295. J Clin Invest. 2022. PMID: 34981776 Free PMC article.

2

AAV8-mediated hepatic expression of acid sphingomyelinase corrects the metabolic defect in the visceral organs of a mouse model of Niemann-Pick disease.

Barbon CM, Ziegler RJ, Li C, Armentano D, Cherry M, Desnick RJ, Schuchman EH, Cheng SH. Barbon CM, et al. Mol Ther. 2005 Sep;12(3):431-40. doi: 10.1016/j.ymthe.2005.03.011. Mol Ther. 2005. PMID: 16099409 Free article.

3

Adeno-associated virus-mediated expression of acid sphingomyelinase decreases atherosclerotic lesion formation in apolipoprotein E(-/-) mice.

Leger AJ, Mosquea LM, Li L, Chuang W, Pacheco J, Taylor K, Luo Z, Piepenhagen P, Ziegler R, Moreland R, Urabe A, Jiang C, Cheng SH, Yew NS. Leger AJ, et al. Among authors: ziegler r. J Gene Med. 2011 Jun;13(6):324-32. doi: 10.1002/jgm.1575. J Gene Med. 2011. PMID: 21674735

4

Ability of adeno-associated virus serotype 8-mediated hepatic expression of acid alpha-glucosidase to correct the biochemical and motor function deficits of presymptomatic and symptomatic Pompe mice.

Ziegler RJ, Bercury SD, Fidler J, Zhao MA, Foley J, Taksir TV, Ryan S, Hodges BL, Scheule RK, Shihabuddin LS, Cheng SH. Ziegler RJ, et al. Hum Gene Ther. 2008 Jun;19(6):609-21. doi: 10.1089/hum.2008.010. Hum Gene Ther. 2008. PMID: 18500944

5

Evaluation of systemic follistatin as an adjuvant to stimulate muscle repair and improve motor function in Pompe mice.

Foley JW, Bercury SD, Finn P, Cheng SH, Scheule RK, Ziegler RJ. Foley JW, et al. Mol Ther. 2010 Sep;18(9):1584-91. doi: 10.1038/mt.2010.110. Epub 2010 Jun 15. Mol Ther. 2010. PMID: 20551907 Free PMC article.

6

Systemic Insulin-like growth factor-1 reverses hypoalgesia and improves mobility in a mouse model of diabetic peripheral neuropathy.

Chu Q, Moreland R, Yew NS, Foley J, Ziegler R, Scheule RK. Chu Q, et al. Among authors: ziegler r. Mol Ther. 2008 Aug;16(8):1400-8. doi: 10.1038/mt.2008.115. Epub 2008 Jun 10. Mol Ther. 2008. PMID: 18545223 Free article.

7

Distribution of acid sphingomyelinase in rodent and non-human primate brain after intracerebroventricular infusion.

Ziegler RJ, Salegio EA, Dodge JC, Bringas J, Treleaven CM, Bercury SD, Tamsett TJ, Shihabuddin L, Hadaczek P, Fiandaca M, Bankiewicz K, Scheule RK. Ziegler RJ, et al. Exp Neurol. 2011 Oct;231(2):261-71. doi: 10.1016/j.expneurol.2011.06.019. Epub 2011 Jul 14. Exp Neurol. 2011. PMID: 21777586

8

AAV2 vector harboring a liver-restricted promoter facilitates sustained expression of therapeutic levels of alpha-galactosidase A and the induction of immune tolerance in Fabry mice.

Ziegler RJ, Lonning SM, Armentano D, Li C, Souza DW, Cherry M, Ford C, Barbon CM, Desnick RJ, Gao G, Wilson JM, Peluso R, Godwin S, Carter BJ, Gregory RJ, Wadsworth SC, Cheng SH. Ziegler RJ, et al. Mol Ther. 2004 Feb;9(2):231-40. doi: 10.1016/j.ymthe.2003.11.015. Mol Ther. 2004. PMID: 14759807 Free article.

9

Pulmonary delivery of recombinant acid sphingomyelinase improves clearance of lysosomal sphingomyelin from the lungs of a murine model of Niemann-Pick disease.

Ziegler RJ, Brown C, Barbon CM, D'Angona AM, Schuchman EH, Andrews L, Thurberg BL, McPherson JM, Karey KP, Cheng SH. Ziegler RJ, et al. Mol Genet Metab. 2009 May;97(1):35-42. doi: 10.1016/j.ymgme.2009.01.008. Epub 2009 Jan 25. Mol Genet Metab. 2009. PMID: 19231265

10

Combination brain and systemic injections of AAV provide maximal functional and survival benefits in the Niemann-Pick mouse.

Passini MA, Bu J, Fidler JA, Ziegler RJ, Foley JW, Dodge JC, Yang WW, Clarke J, Taksir TV, Griffiths DA, Zhao MA, O'Riordan CR, Schuchman EH, Shihabuddin LS, Cheng SH. Passini MA, et al. Among authors: ziegler rj. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9505-10. doi: 10.1073/pnas.0703509104. Epub 2007 May 21. Proc Natl Acad Sci U S A. 2007. PMID: 17517638 Free PMC article.

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