Xu X - Search Results

1

Discovery of N-(4-(Benzyloxy)-phenyl)-sulfonamide Derivatives as Novel Antagonists of the Human Androgen Receptor Targeting the Activation Function 2.

Chai X, Sun H, Zhou W, Chen C, Shan L, Yang Y, He J, Pang J, Yang L, Wang X, Cui S, Fu Y, Xu X, Xu L, Yao X, Li D, Hou T. Chai X, et al. Among authors: xu l, xu x. J Med Chem. 2022 Feb 10;65(3):2507-2521. doi: 10.1021/acs.jmedchem.1c01938. Epub 2022 Jan 25. J Med Chem. 2022. PMID: 35077161

2

Serum thymidine kinase 1 reflects the progression of pre-malignant and malignant tumors during therapy.

Xu XH, Zhang YM, Shu XH, Shan LH, Wang ZW, Zhou YL, Wen HK, He F, He E, Skog S. Xu XH, et al. Mol Med Rep. 2008 Sep-Oct;1(5):705-11. doi: 10.3892/mmr_00000017. Mol Med Rep. 2008. PMID: 21479474

3

Novel androgen receptor antagonist identified by structure-based virtual screening, structural optimization, and biological evaluation.

Tang Q, Fu W, Zhang M, Wang E, Shan L, Chai X, Pang J, Wang X, Xu X, Xu L, Li D, Sheng R, Hou T. Tang Q, et al. Among authors: xu l, xu x. Eur J Med Chem. 2020 Apr 15;192:112156. doi: 10.1016/j.ejmech.2020.112156. Epub 2020 Feb 21. Eur J Med Chem. 2020. PMID: 32114360

4

Discovery of novel antagonists targeting the DNA binding domain of androgen receptor by integrated docking-based virtual screening and bioassays.

Pang JP, Shen C, Zhou WF, Wang YX, Shan LH, Chai X, Shao Y, Hu XP, Zhu F, Zhu DY, Xiao L, Xu L, Xu XH, Li D, Hou TJ. Pang JP, et al. Among authors: xu l, xu xh. Acta Pharmacol Sin. 2022 Jan;43(1):229-239. doi: 10.1038/s41401-021-00632-5. Epub 2021 Mar 25. Acta Pharmacol Sin. 2022. PMID: 33767381 Free PMC article.

5

Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers.

Fu W, Zhang M, Liao J, Tang Q, Lei Y, Gong Z, Shan L, Duan M, Chai X, Pang J, Tang C, Wang X, Xu X, Li D, Sheng R, Hou T. Fu W, et al. Among authors: xu x. J Med Chem. 2021 Dec 9;64(23):17221-17238. doi: 10.1021/acs.jmedchem.1c01287. Epub 2021 Nov 22. J Med Chem. 2021. PMID: 34809430

6

Knockdown of insulin-like growth factor 1 receptor enhances chemosensitivity to cisplatin in human lung adenocarcinoma A549 cells.

Dong A, Kong M, Ma Z, Qian J, Cheng H, Xu X. Dong A, et al. Among authors: xu x. Acta Biochim Biophys Sin (Shanghai). 2008 Jun;40(6):497-504. doi: 10.1111/j.1745-7270.2008.00429.x. Acta Biochim Biophys Sin (Shanghai). 2008. PMID: 18535748 Free article.

7

Indole-2-Carboxamide Derivative LG25 Inhibits Triple-Negative Breast Cancer Growth By Suppressing Akt/mTOR/NF-κB Signalling Pathway.

Xu X, Rajamanickam V, Shu S, Liu Z, Yan T, He J, Liu Z, Guo G, Liang G, Wang Y. Xu X, et al. Drug Des Devel Ther. 2019 Oct 11;13:3539-3550. doi: 10.2147/DDDT.S216542. eCollection 2019. Drug Des Devel Ther. 2019. PMID: 31631978 Free PMC article.

8

[shRNA-mediated insulin-like growth factor I receptor gene silencing inhibits cell proliferation, induces cell apoptosis, and suppresses tumor growth in non-small cell lung cancer: in vitro and in vivo experiments].

Dong AQ, Kong MJ, Ma ZY, Qian JF, Fan JQ, Xu XH. Dong AQ, et al. Zhonghua Yi Xue Za Zhi. 2007 Jun 5;87(21):1506-9. Zhonghua Yi Xue Za Zhi. 2007. PMID: 17785094 Chinese.

9

Selective targeting of the TLR4 co-receptor, MD2, prevents colon cancer growth and lung metastasis.

Rajamanickam V, Yan T, Xu S, Hui J, Xu X, Ren L, Liu Z, Liang G, Wang O, Wang Y. Rajamanickam V, et al. Among authors: xu s, xu x. Int J Biol Sci. 2020 Feb 17;16(8):1288-1302. doi: 10.7150/ijbs.39098. eCollection 2020. Int J Biol Sci. 2020. PMID: 32210720 Free PMC article.

10

Use of Shenhuang paste on Shenque point improves chemotherapy induced gastrointestinal toxicity in breast cancer: A protocol for randomized controlled trial.

Wang R, Shi Y, Xie X, Ge Q, Xu J, Sun Q, Xu X. Wang R, et al. Among authors: xu x, xu j. Medicine (Baltimore). 2021 Apr 16;100(15):e25097. doi: 10.1097/MD.0000000000025097. Medicine (Baltimore). 2021. PMID: 33847614 Free PMC article.

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