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Personalized phosphoproteomics identifies functional signaling.
Needham EJ, Hingst JR, Parker BL, Morrison KR, Yang G, Onslev J, Kristensen JM, Højlund K, Ling NXY, Oakhill JS, Richter EA, Kiens B, Petersen J, Pehmøller C, James DE, Wojtaszewski JFP, Humphrey SJ. Needham EJ, et al. Among authors: humphrey sj. Nat Biotechnol. 2022 Apr;40(4):576-584. doi: 10.1038/s41587-021-01099-9. Epub 2021 Dec 2. Nat Biotechnol. 2022. PMID: 34857927
Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate.
Duan X, Norris DM, Humphrey SJ, Yang P, Cooke KC, Bultitude WP, Parker BL, Conway OJ, Burchfield JG, Krycer JR, Brodsky FM, James DE, Fazakerley DJ. Duan X, et al. Among authors: humphrey sj. Biochem J. 2022 Jun 17;479(11):1237-1256. doi: 10.1042/BCJ20220153. Biochem J. 2022. PMID: 35594055 Free PMC article.
A high-content endogenous GLUT4 trafficking assay reveals new aspects of adipocyte biology.
Diaz-Vegas A, Norris DM, Jall-Rogg S, Cooke KC, Conway OJ, Shun-Shion AS, Duan X, Potter M, van Gerwen J, Baird HJ, Humphrey SJ, James DE, Fazakerley DJ, Burchfield JG. Diaz-Vegas A, et al. Among authors: humphrey sj. Life Sci Alliance. 2022 Oct 25;6(1):e202201585. doi: 10.26508/lsa.202201585. Print 2023 Jan. Life Sci Alliance. 2022. PMID: 36283703 Free PMC article.
RagC phosphorylation autoregulates mTOR complex 1.
Yang G, Humphrey SJ, Murashige DS, Francis D, Wang QP, Cooke KC, Neely GG, James DE. Yang G, et al. Among authors: humphrey sj. EMBO J. 2019 Feb 1;38(3):e99548. doi: 10.15252/embj.201899548. Epub 2018 Dec 14. EMBO J. 2019. PMID: 30552228 Free PMC article.
Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis.
Kearney AL, Norris DM, Ghomlaghi M, Kin Lok Wong M, Humphrey SJ, Carroll L, Yang G, Cooke KC, Yang P, Geddes TA, Shin S, Fazakerley DJ, Nguyen LK, James DE, Burchfield JG. Kearney AL, et al. Among authors: humphrey sj. Elife. 2021 Jul 13;10:e66942. doi: 10.7554/eLife.66942. Elife. 2021. PMID: 34253290 Free PMC article.
105 results