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AICAr suppresses cell proliferation by inducing NTP and dNTP pool imbalances in acute lymphoblastic leukemia cells.
Du L, Yang F, Fang H, Sun H, Chen Y, Xu Y, Li H, Zheng L, Zhou BS. Du L, et al. Among authors: li h. FASEB J. 2019 Mar;33(3):4525-4537. doi: 10.1096/fj.201801559RR. Epub 2019 Jan 31. FASEB J. 2019. PMID: 30702927
Our data indicate that RNA transcription inhibition and DNA replication stress induced by NTP and dNTP pool imbalances might play a key role in AICAr-mediated cytotoxic effects on ALL cells, suggesting a potential clinical application of AICAr in future ALL therapy.-Du, L., Yang, …
Our data indicate that RNA transcription inhibition and DNA replication stress induced by NTP and dNTP pool imbalances might play a key role …
Blocking ATM-dependent NF-κB pathway overcomes niche protection and improves chemotherapy response in acute lymphoblastic leukemia.
Chen YL, Tang C, Zhang MY, Huang WL, Xu Y, Sun HY, Yang F, Song LL, Wang H, Mu LL, Li MH, Zheng WW, Miao Y, Ding LX, Li BS, Shen SH, Liu SL, Li H, Zhu ZQ, Chen HW, Tang ZH, Chen J, Hong DL, Chen HZ, Duan CW, Zhou BS. Chen YL, et al. Among authors: li bs, li h, li mh. Leukemia. 2019 Oct;33(10):2365-2378. doi: 10.1038/s41375-019-0458-0. Epub 2019 Apr 2. Leukemia. 2019. PMID: 30940905
Chemotherapy and mismatch repair deficiency cooperate to fuel TP53 mutagenesis and ALL relapse.
Yang F, Brady SW, Tang C, Sun H, Du L, Barz MJ, Ma X, Chen Y, Fang H, Li X, Kolekar P, Pathak O, Cai J, Ding L, Wang T, von Stackelberg A, Shen S, Eckert C, Klco JM, Chen H, Duan C, Liu Y, Li H, Li B, Kirschner-Schwabe R, Zhang J, Zhou BS. Yang F, et al. Among authors: li x, li h, li b. Nat Cancer. 2021 Aug;2(8):819-834. doi: 10.1038/s43018-021-00230-8. Epub 2021 Jul 22. Nat Cancer. 2021. PMID: 35122027
Antileukemic effects of topoisomerase I inhibitors mediated by de-SUMOylase SENP1.
Niu Q, Hou W, Yan Y, Sun S, Lin Y, Fang H, Ma C, Dong C, Cheng Y, Xu Y, Ding M, Wang S, Cui Z, Chen Y, Li H, Li H, Xiao N. Niu Q, et al. Among authors: li h. Biochim Biophys Acta Mol Basis Dis. 2022 Dec 1;1868(12):166492. doi: 10.1016/j.bbadis.2022.166492. Epub 2022 Jul 16. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35850175 Free article.
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