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Selective targeting of TGF-β activation to treat fibroinflammatory airway disease.
Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL. Minagawa S, et al. Among authors: nishimura sl. Sci Transl Med. 2014 Jun 18;6(241):241ra79. doi: 10.1126/scitranslmed.3008074. Sci Transl Med. 2014. PMID: 24944194 Free PMC article.
Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8.
Fenton TM, Kelly A, Shuttleworth EE, Smedley C, Atakilit A, Powrie F, Campbell S, Nishimura SL, Sheppard D, Levison S, Worthington JJ, Lehtinen MJ, Travis MA. Fenton TM, et al. Among authors: nishimura sl. Mucosal Immunol. 2017 May;10(3):624-634. doi: 10.1038/mi.2016.94. Epub 2016 Oct 26. Mucosal Immunol. 2017. PMID: 27782111 Free PMC article.
Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture.
Markovics JA, Araya J, Cambier S, Somanath S, Gline S, Jablons D, Hill A, Wolters PJ, Nishimura SL. Markovics JA, et al. Among authors: nishimura sl. J Biol Chem. 2011 Oct 21;286(42):36864-74. doi: 10.1074/jbc.M111.276790. Epub 2011 Aug 30. J Biol Chem. 2011. PMID: 21878622 Free PMC article.
TGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease.
Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL. Hashimoto M, et al. Among authors: nishimura sl. J Immunol. 2015 Aug 1;195(3):1182-90. doi: 10.4049/jimmunol.1500348. Epub 2015 Jun 24. J Immunol. 2015. PMID: 26109638 Free PMC article.
Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway.
Markovics JA, Araya J, Cambier S, Jablons D, Hill A, Wolters PJ, Nishimura SL. Markovics JA, et al. Among authors: nishimura sl. J Biol Chem. 2010 Aug 6;285(32):24695-706. doi: 10.1074/jbc.M110.113977. Epub 2010 Jun 2. J Biol Chem. 2010. PMID: 20519498 Free PMC article.
C., Sheppard, D., Barzcak, A., Xiao, Y., Erle, D. J., and Nishimura, S. L. (2007) J. Clin. Invest. 117, 3551-3562; Su, H., Kim, H., Pawlikowska, L., Kitamura, H., Shen, F., Cambier, S., Markovics, J., Lawton, M. ...Y., and Nishimura, S. L. (2010 …
C., Sheppard, D., Barzcak, A., Xiao, Y., Erle, D. J., and Nishimura, S. L. (2007) J. Clin. Invest. 117, 3551-3562; Su, H., Kim …
3,058 results