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Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.
Mühlethaler T, Milanos L, Ortega JA, Blum TB, Gioia D, Roy B, Prota AE, Cavalli A, Steinmetz MO. Mühlethaler T, et al. Among authors: steinmetz mo. Angew Chem Int Ed Engl. 2022 Jun 20;61(25):e202204052. doi: 10.1002/anie.202204052. Epub 2022 Apr 25. Angew Chem Int Ed Engl. 2022. PMID: 35404502 Free PMC article.
Structural basis of tubulin tyrosination by tubulin tyrosine ligase.
Prota AE, Magiera MM, Kuijpers M, Bargsten K, Frey D, Wieser M, Jaussi R, Hoogenraad CC, Kammerer RA, Janke C, Steinmetz MO. Prota AE, et al. Among authors: steinmetz mo. J Cell Biol. 2013 Feb 4;200(3):259-70. doi: 10.1083/jcb.201211017. Epub 2013 Jan 28. J Cell Biol. 2013. PMID: 23358242 Free PMC article.
Structural basis of microtubule stabilization by laulimalide and peloruside A.
Prota AE, Bargsten K, Northcote PT, Marsh M, Altmann KH, Miller JH, Díaz JF, Steinmetz MO. Prota AE, et al. Among authors: steinmetz mo. Angew Chem Int Ed Engl. 2014 Feb 3;53(6):1621-5. doi: 10.1002/anie.201307749. Epub 2014 Jan 27. Angew Chem Int Ed Engl. 2014. PMID: 24470331
Fast native-SAD phasing for routine macromolecular structure determination.
Weinert T, Olieric V, Waltersperger S, Panepucci E, Chen L, Zhang H, Zhou D, Rose J, Ebihara A, Kuramitsu S, Li D, Howe N, Schnapp G, Pautsch A, Bargsten K, Prota AE, Surana P, Kottur J, Nair DT, Basilico F, Cecatiello V, Pasqualato S, Boland A, Weichenrieder O, Wang BC, Steinmetz MO, Caffrey M, Wang M. Weinert T, et al. Among authors: steinmetz mo. Nat Methods. 2015 Feb;12(2):131-3. doi: 10.1038/nmeth.3211. Epub 2014 Dec 15. Nat Methods. 2015. PMID: 25506719
Antivascular and antitumor properties of the tubulin-binding chalcone TUB091.
Canela MD, Noppen S, Bueno O, Prota AE, Bargsten K, Sáez-Calvo G, Jimeno ML, Benkheil M, Ribatti D, Velázquez S, Camarasa MJ, Díaz JF, Steinmetz MO, Priego EM, Pérez-Pérez MJ, Liekens S. Canela MD, et al. Among authors: steinmetz mo. Oncotarget. 2017 Feb 28;8(9):14325-14342. doi: 10.18632/oncotarget.9527. Oncotarget. 2017. PMID: 27224920 Free PMC article.
Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes.
Doodhi H, Prota AE, Rodríguez-García R, Xiao H, Custar DW, Bargsten K, Katrukha EA, Hilbert M, Hua S, Jiang K, Grigoriev I, Yang CH, Cox D, Horwitz SB, Kapitein LC, Akhmanova A, Steinmetz MO. Doodhi H, et al. Among authors: steinmetz mo. Curr Biol. 2016 Jul 11;26(13):1713-1721. doi: 10.1016/j.cub.2016.04.053. Epub 2016 Jun 16. Curr Biol. 2016. PMID: 27321995 Free article.
241 results