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PARP1-PKM2 Axis Mediates Right Ventricular Failure Associated With Pulmonary Arterial Hypertension.
Shimauchi T, Boucherat O, Yokokawa T, Grobs Y, Wu W, Orcholski M, Martineau S, Omura J, Tremblay E, Shimauchi K, Nadeau V, Breuils-Bonnet S, Paulin R, Potus F, Provencher S, Bonnet S. Shimauchi T, et al. Among authors: orcholski m. JACC Basic Transl Sci. 2022 Mar 16;7(4):384-403. doi: 10.1016/j.jacbts.2022.01.005. eCollection 2022 Apr. JACC Basic Transl Sci. 2022. PMID: 35540097 Free PMC article.
Inhibition of CHK 1 (Checkpoint Kinase 1) Elicits Therapeutic Effects in Pulmonary Arterial Hypertension.
Bourgeois A, Bonnet S, Breuils-Bonnet S, Habbout K, Paradis R, Tremblay E, Lampron MC, Orcholski ME, Potus F, Bertero T, Peterlini T, Chan SY, Norris KA, Paulin R, Provencher S, Boucherat O. Bourgeois A, et al. Among authors: orcholski me. Arterioscler Thromb Vasc Biol. 2019 Aug;39(8):1667-1681. doi: 10.1161/ATVBAHA.119.312537. Epub 2019 May 16. Arterioscler Thromb Vasc Biol. 2019. PMID: 31092016 Free PMC article.
Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in Pulmonary Arterial Hypertension.
Vitry G, Paulin R, Grobs Y, Lampron MC, Shimauchi T, Lemay SE, Tremblay E, Habbout K, Awada C, Bourgeois A, Nadeau V, Paradis R, Breuils-Bonnet S, Roux-Dalvai F, Orcholski M, Potus F, Provencher S, Boucherat O, Bonnet S. Vitry G, et al. Among authors: orcholski m. Am J Respir Crit Care Med. 2021 Mar 1;203(5):614-627. doi: 10.1164/rccm.202003-0627OC. Am J Respir Crit Care Med. 2021. PMID: 33021405
Implication of EZH2 in the Pro-Proliferative and Apoptosis-Resistant Phenotype of Pulmonary Artery Smooth Muscle Cells in PAH: A Transcriptomic and Proteomic Approach.
Habbout K, Omura J, Awada C, Bourgeois A, Grobs Y, Krishna V, Breuils-Bonnet S, Tremblay E, Mkannez G, Martineau S, Nadeau V, Roux-Dalvai F, Orcholski M, Jeyaseelan J, Gutstein D, Potus F, Provencher S, Bonnet S, Paulin R, Boucherat O. Habbout K, et al. Among authors: orcholski m. Int J Mol Sci. 2021 Mar 15;22(6):2957. doi: 10.3390/ijms22062957. Int J Mol Sci. 2021. PMID: 33803922 Free PMC article.
Preclinical Investigation of Trifluoperazine as a Novel Therapeutic Agent for the Treatment of Pulmonary Arterial Hypertension.
Grobs Y, Awada C, Lemay SE, Romanet C, Bourgeois A, Toro V, Nadeau V, Shimauchi K, Orcholski M, Breuils-Bonnet S, Tremblay E, Provencher S, Paulin R, Boucherat O, Bonnet S. Grobs Y, et al. Among authors: orcholski m. Int J Mol Sci. 2021 Mar 13;22(6):2919. doi: 10.3390/ijms22062919. Int J Mol Sci. 2021. PMID: 33805714 Free PMC article.
Potential for inhibition of checkpoint kinases 1/2 in pulmonary fibrosis and secondary pulmonary hypertension.
Wu WH, Bonnet S, Shimauchi T, Toro V, Grobs Y, Romanet C, Bourgeois A, Vitry G, Omura J, Tremblay E, Nadeau V, Orcholski M, Breuils-Bonnet S, Martineau S, Ferraro P, Potus F, Paulin R, Provencher S, Boucherat O. Wu WH, et al. Among authors: orcholski m. Thorax. 2022 Mar;77(3):247-258. doi: 10.1136/thoraxjnl-2021-217377. Epub 2021 Jul 5. Thorax. 2022. PMID: 34226205
Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension.
Chakraborty A, Nathan A, Orcholski M, Agarwal S, Shamskhou EA, Auer N, Mitra A, Guardado ES, Swaminathan G, Condon DF, Yu J, McCarra M, Juul NH, Mallory A, Guzman-Hernandez RA, Yuan K, Rojas V, Crossno JT, Yung LM, Yu PB, Spencer T, Winn RA, Frump A, Karoor V, Lahm T, Hedlin H, Fineman JR, Lafyatis R, Knutsen CNF, Alvira CM, Cornfield DN, de Jesus Perez VA. Chakraborty A, et al. Among authors: orcholski m. Eur Respir J. 2023 Jun 8;61(6):2201625. doi: 10.1183/13993003.01625-2022. Print 2023 Jun. Eur Respir J. 2023. PMID: 37024132 Free PMC article.
Whole-exome sequencing reveals TopBP1 as a novel gene in idiopathic pulmonary arterial hypertension.
de Jesus Perez VA, Yuan K, Lyuksyutova MA, Dewey F, Orcholski ME, Shuffle EM, Mathur M, Yancy L Jr, Rojas V, Li CG, Cao A, Alastalo TP, Khazeni N, Cimprich KA, Butte AJ, Ashley E, Zamanian RT. de Jesus Perez VA, et al. Among authors: orcholski me. Am J Respir Crit Care Med. 2014 May 15;189(10):1260-72. doi: 10.1164/rccm.201310-1749OC. Am J Respir Crit Care Med. 2014. PMID: 24702692 Free PMC article.
Drug-induced pulmonary arterial hypertension: a primer for clinicians and scientists.
Orcholski ME, Yuan K, Rajasingh C, Tsai H, Shamskhou EA, Dhillon NK, Voelkel NF, Zamanian RT, de Jesus Perez VA. Orcholski ME, et al. Am J Physiol Lung Cell Mol Physiol. 2018 Jun 1;314(6):L967-L983. doi: 10.1152/ajplung.00553.2017. Epub 2018 Feb 8. Am J Physiol Lung Cell Mol Physiol. 2018. PMID: 29417823 Free PMC article.
27 results