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The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunit.
Bradel-Tretheway BG, Kelley Z, Chakraborty-Sett S, Takimoto T, Kim B, Dewhurst S. Bradel-Tretheway BG, et al. Among authors: dewhurst s. J Gen Virol. 2008 Dec;89(Pt 12):2923-2932. doi: 10.1099/vir.0.2008/006254-0. J Gen Virol. 2008. PMID: 19008377 Free PMC article.
Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines.
Rodriguez L, Blanco-Lobo P, Reilly EC, Maehigashi T, Nogales A, Smith A, Topham DJ, Dewhurst S, Kim B, Martínez-Sobrido L. Rodriguez L, et al. Among authors: dewhurst s. Viruses. 2019 Oct 10;11(10):928. doi: 10.3390/v11100928. Viruses. 2019. PMID: 31658679 Free PMC article.
A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus.
Smith A, Rodriguez L, El Ghouayel M, Nogales A, Chamberlain JM, Sortino K, Reilly E, Feng C, Topham DJ, Martínez-Sobrido L, Dewhurst S. Smith A, et al. Among authors: dewhurst s. J Virol. 2020 Jan 31;94(4):e01065-19. doi: 10.1128/JVI.01065-19. Print 2020 Jan 31. J Virol. 2020. PMID: 31748399 Free PMC article.
333 results