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cis-[RuCl(BzCN)(bipy)(dppe)]PF6 induces anti-angiogenesis and apoptosis by a mechanism of caspase-dependent involving DNA damage, PARP activation, and Tp53 induction in Ehrlich tumor cells.
Magalhães LF, Mello-Andrade F, Pires WC, Silva HD, da Silva PFF, Macedo LM, Henrique de Castro C, Carneiro CC, Cardoso CG, de Melo Reis PR, Camargo de Oliveira L, Caetano RR, Batista AA, Silveira-Lacerda EP. Magalhães LF, et al. Among authors: da silva pff. Chem Biol Interact. 2017 Dec 25;278:101-113. doi: 10.1016/j.cbi.2017.09.013. Epub 2017 Sep 19. Chem Biol Interact. 2017. PMID: 28935426
Ruthenium(II)/Benzonitrile Complex Induces Cytotoxic Effect in Sarcoma-180 Cells by Caspase-Mediated and Tp53/p21-Mediated Apoptosis, with Moderate Brine Shrimp Toxicity.
Faria RS, Silva HD, Mello-Andrade F, Pires WC, de Castro Pereira F, de Lima AP, de Fátima Oliveira Santos S, Teixeira TM, da Silva PFF, Naves PLF, Batista AA, da Silva Oliveira RJ, Reis RM, de Paula Silveira-Lacerda E. Faria RS, et al. Among authors: da silva pff. Biol Trace Elem Res. 2020 Dec;198(2):669-680. doi: 10.1007/s12011-020-02098-8. Epub 2020 Apr 8. Biol Trace Elem Res. 2020. PMID: 32266641
Heterobimetallic Ru(ii)/Fe(ii) complexes as potent anticancer agents against breast cancer cells, inducing apoptosis through multiple targets.
Guedes APM , Mello-Andrade F , Pires WC , de Sousa MAM , da Silva PFF , de Camargo MS , Gemeiner H , Amauri MA , Gomes Cardoso C , de Melo Reis PR , Silveira-Lacerda EP , Batista AA . Guedes APM , et al. Among authors: da silva pff. Metallomics. 2020 Apr 1;12(4):547-561. doi: 10.1039/c9mt00272c. Epub 2020 Feb 28. Metallomics. 2020. PMID: 32108850
Ruthenium (II)/allopurinol complex inhibits breast cancer progression via multiple targets.
Travassos IO, Mello-Andrade F, Caldeira RP, Pires WC, da Silva PFF, Correa RS, Teixeira T, Martins-Oliveira A, Batista AA, de Silveira-Lacerda EP. Travassos IO, et al. Among authors: da silva pff. J Biol Inorg Chem. 2021 Jun;26(4):385-401. doi: 10.1007/s00775-021-01862-y. Epub 2021 Apr 10. J Biol Inorg Chem. 2021. PMID: 33837856