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Probing GPCR Dimerization Using Peptides.
Farooq Z, Howell LA, McCormick PJ. Farooq Z, et al. Among authors: howell la. Front Endocrinol (Lausanne). 2022 Jul 14;13:843770. doi: 10.3389/fendo.2022.843770. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35909575 Free PMC article. Review.
Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure.
Busnelli M, Kleinau G, Muttenthaler M, Stoev S, Manning M, Bibic L, Howell LA, McCormick PJ, Di Lascio S, Braida D, Sala M, Rovati GE, Bellini T, Chini B. Busnelli M, et al. Among authors: howell la. J Med Chem. 2016 Aug 11;59(15):7152-66. doi: 10.1021/acs.jmedchem.6b00564. Epub 2016 Jul 28. J Med Chem. 2016. PMID: 27420737 Free article.
Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease.
Moreno-Delgado D, Puigdellívol M, Moreno E, Rodríguez-Ruiz M, Botta J, Gasperini P, Chiarlone A, Howell LA, Scarselli M, Casadó V, Cortés A, Ferré S, Guzmán M, Lluís C, Alberch J, Canela EI, Ginés S, McCormick PJ. Moreno-Delgado D, et al. Among authors: howell la. Elife. 2020 Jun 9;9:e51093. doi: 10.7554/eLife.51093. Elife. 2020. PMID: 32513388 Free PMC article.
Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum.
Moreno E, Chiarlone A, Medrano M, Puigdellívol M, Bibic L, Howell LA, Resel E, Puente N, Casarejos MJ, Perucho J, Botta J, Suelves N, Ciruela F, Ginés S, Galve-Roperh I, Casadó V, Grandes P, Lutz B, Monory K, Canela EI, Lluís C, McCormick PJ, Guzmán M. Moreno E, et al. Among authors: howell la. Neuropsychopharmacology. 2018 Apr;43(5):964-977. doi: 10.1038/npp.2017.12. Epub 2017 Jan 19. Neuropsychopharmacology. 2018. PMID: 28102227 Free PMC article.
Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine.
Navarro G, Quiroz C, Moreno-Delgado D, Sierakowiak A, McDowell K, Moreno E, Rea W, Cai NS, Aguinaga D, Howell LA, Hausch F, Cortés A, Mallol J, Casadó V, Lluís C, Canela EI, Ferré S, McCormick PJ. Navarro G, et al. Among authors: howell la. J Neurosci. 2015 Apr 29;35(17):6639-53. doi: 10.1523/JNEUROSCI.4364-14.2015. J Neurosci. 2015. PMID: 25926444 Free PMC article.
Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors.
Viñals X, Moreno E, Lanfumey L, Cordomí A, Pastor A, de La Torre R, Gasperini P, Navarro G, Howell LA, Pardo L, Lluís C, Canela EI, McCormick PJ, Maldonado R, Robledo P. Viñals X, et al. Among authors: howell la. PLoS Biol. 2015 Jul 9;13(7):e1002194. doi: 10.1371/journal.pbio.1002194. eCollection 2015 Jul. PLoS Biol. 2015. PMID: 26158621 Free PMC article.
Design and synthesis of threading intercalators to target DNA.
Howell LA, Gulam R, Mueller A, O'Connell MA, Searcey M. Howell LA, et al. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6956-9. doi: 10.1016/j.bmcl.2010.09.128. Epub 2010 Oct 7. Bioorg Med Chem Lett. 2010. PMID: 20980148
55 results