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Possible mechanism for improving the endogenous immune system through the blockade of peripheral μ-opioid receptors by treatment with naldemedine.
Gondoh E, Hamada Y, Mori T, Iwazawa Y, Shinohara A, Narita M, Sato D, Tezuka H, Yamauchi T, Tsujimura M, Yoshida S, Tanaka K, Yamashita K, Akatori H, Higashiyama K, Arakawa K, Suda Y, Miyano K, Iseki M, Inada E, Kuzumaki N, Narita M. Gondoh E, et al. Among authors: miyano k. Br J Cancer. 2022 Nov;127(8):1565-1574. doi: 10.1038/s41416-022-01928-x. Epub 2022 Aug 9. Br J Cancer. 2022. PMID: 35945243 Free PMC article.
Sensation of abdominal pain induced by peritoneal carcinomatosis is accompanied by changes in the expression of substance P and μ-opioid receptors in the spinal cord of mice.
Suzuki M, Narita M, Hasegawa M, Furuta S, Kawamata T, Ashikawa M, Miyano K, Yanagihara K, Chiwaki F, Ochiya T, Suzuki T, Matoba M, Sasaki H, Uezono Y. Suzuki M, et al. Among authors: miyano k. Anesthesiology. 2012 Oct;117(4):847-56. doi: 10.1097/ALN.0b013e31826a4ac8. Anesthesiology. 2012. PMID: 22913923 Free article.
Usefulness for the combination of G-protein- and β-arrestin-biased ligands of μ-opioid receptors: Prevention of antinociceptive tolerance.
Mori T, Kuzumaki N, Arima T, Narita M, Tateishi R, Kondo T, Hamada Y, Kuwata H, Kawata M, Yamazaki M, Sugita K, Matsuzawa A, Baba K, Yamauchi T, Higashiyama K, Nonaka M, Miyano K, Uezono Y, Narita M. Mori T, et al. Among authors: miyano k. Mol Pain. 2017 Jan-Dec;13:1744806917740030. doi: 10.1177/1744806917740030. Mol Pain. 2017. PMID: 29056067 Free PMC article.
Further investigation of the rapid-onset and short-duration action of the G protein-biased μ-ligand oliceridine.
Mori T, Takemura Y, Arima T, Iwase Y, Narita M, Miyano K, Hamada Y, Suda Y, Matsuzawa A, Sugita K, Matsumura S, Sasaki S, Yamauchi T, Higashiyama K, Uezono Y, Yamazaki M, Kuzumaki N, Narita M. Mori T, et al. Among authors: miyano k. Biochem Biophys Res Commun. 2021 Jan 1;534:988-994. doi: 10.1016/j.bbrc.2020.10.053. Epub 2020 Nov 1. Biochem Biophys Res Commun. 2021. PMID: 33139013
Inhibition of endothelin A receptor by a novel, selective receptor antagonist enhances morphine-induced analgesia: Possible functional interaction of dimerized endothelin A and μ-opioid receptors.
Kuroda Y, Nonaka M, Kamikubo Y, Ogawa H, Murayama T, Kurebayashi N, Sakairi H, Miyano K, Komatsu A, Dodo T, Nakano-Ito K, Yamaguchi K, Sakurai T, Iseki M, Hayashida M, Uezono Y. Kuroda Y, et al. Among authors: miyano k. Biomed Pharmacother. 2021 Sep;141:111800. doi: 10.1016/j.biopha.2021.111800. Epub 2021 Jun 24. Biomed Pharmacother. 2021. PMID: 34175819 Free article.
In Vitro Analyses of Spinach-Derived Opioid Peptides, Rubiscolins: Receptor Selectivity and Intracellular Activities through G Protein- and β-Arrestin-Mediated Pathways.
Karasawa Y, Miyano K, Fujii H, Mizuguchi T, Kuroda Y, Nonaka M, Komatsu A, Ohshima K, Yamaguchi M, Yamaguchi K, Iseki M, Uezono Y, Hayashida M. Karasawa Y, et al. Among authors: miyano k. Molecules. 2021 Oct 8;26(19):6079. doi: 10.3390/molecules26196079. Molecules. 2021. PMID: 34641621 Free PMC article.
299 results