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Page 1
Discovery of CH7057288 as an Orally Bioavailable, Selective, and Potent pan-TRK Inhibitor.
Ito T, Kinoshita K, Tomizawa M, Shinohara S, Nishii H, Matsushita M, Hattori K, Kohchi Y, Kohchi M, Hayase T, Watanabe F, Hasegawa K, Tanaka H, Kuramoto S, Takanashi K, Oikawa N. Ito T, et al. Among authors: hattori k. J Med Chem. 2022 Sep 22;65(18):12427-12444. doi: 10.1021/acs.jmedchem.2c01099. Epub 2022 Sep 6. J Med Chem. 2022. PMID: 36066182
9-substituted 6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as highly selective and potent anaplastic lymphoma kinase inhibitors.
Kinoshita K, Kobayashi T, Asoh K, Furuichi N, Ito T, Kawada H, Hara S, Ohwada J, Hattori K, Miyagi T, Hong WS, Park MJ, Takanashi K, Tsukaguchi T, Sakamoto H, Tsukuda T, Oikawa N. Kinoshita K, et al. Among authors: hattori k. J Med Chem. 2011 Sep 22;54(18):6286-94. doi: 10.1021/jm200652u. Epub 2011 Aug 25. J Med Chem. 2011. PMID: 21823617
Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent.
Isshiki Y, Kohchi Y, Iikura H, Matsubara Y, Asoh K, Murata T, Kohchi M, Mizuguchi E, Tsujii S, Hattori K, Miura T, Yoshimura Y, Aida S, Miwa M, Saitoh R, Murao N, Okabe H, Belunis C, Janson C, Lukacs C, Schück V, Shimma N. Isshiki Y, et al. Among authors: hattori k. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1795-801. doi: 10.1016/j.bmcl.2011.01.062. Epub 2011 Jan 21. Bioorg Med Chem Lett. 2011. PMID: 21316218
Design and synthesis of novel prodrugs of 2'-deoxy-2'-methylidenecytidine activated by membrane dipeptidase overexpressed in tumor tissues.
Kohchi Y, Hattori K, Oikawa N, Mizuguchi E, Isshiki Y, Aso K, Yoshinari K, Shirai H, Miwa M, Inagaki Y, Ura M, Ogawa K, Okabe H, Ishitsuka H, Shimma N. Kohchi Y, et al. Among authors: hattori k. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2241-5. doi: 10.1016/j.bmcl.2007.01.066. Epub 2007 Jan 27. Bioorg Med Chem Lett. 2007. PMID: 17306533
A novel pyridazinone derivative as a nonprostanoid PGI2 agonist.
Tsubaki K, Taniguchi K, Tabuchi S, Okitsu O, Hattori K, Seki J, Sakane K, Tanaka H. Tsubaki K, et al. Among authors: hattori k. Bioorg Med Chem Lett. 2000 Dec 18;10(24):2787-90. doi: 10.1016/s0960-894x(00)00571-0. Bioorg Med Chem Lett. 2000. PMID: 11133092
Synthesis of novel antifungal agents (2).
Tsukuda T, Watanabe M, Ontsuka H, Hattori K, Shirai M, Shimma N. Tsukuda T, et al. Among authors: hattori k. Bioorg Med Chem Lett. 1998 Jul 21;8(14):1825-8. doi: 10.1016/s0960-894x(98)00315-1. Bioorg Med Chem Lett. 1998. PMID: 9873441
1,741 results