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Conditional inactivation of the L-type amino acid transporter LAT1 in chondrocytes models idiopathic scoliosis in mice.
Iwahashi S, Lyu J, Tokumura K, Osumi R, Hiraiwa M, Kubo T, Horie T, Demura S, Kawakami N, Saito T, Park G, Fukasawa K, Iezaki T, Suzuki A, Tomizawa A, Ochi H, Hojo H, Ohba S, Hinoi E. Iwahashi S, et al. Among authors: tokumura k. J Cell Physiol. 2022 Nov;237(11):4292-4302. doi: 10.1002/jcp.30883. Epub 2022 Sep 26. J Cell Physiol. 2022. PMID: 36161979
mTORC1 Activation in Osteoclasts Prevents Bone Loss in a Mouse Model of Osteoporosis.
Hiraiwa M, Ozaki K, Yamada T, Iezaki T, Park G, Fukasawa K, Horie T, Kamada H, Tokumura K, Motono M, Kaneda K, Hinoi E. Hiraiwa M, et al. Among authors: tokumura k. Front Pharmacol. 2019 Jun 13;10:684. doi: 10.3389/fphar.2019.00684. eCollection 2019. Front Pharmacol. 2019. PMID: 31263418 Free PMC article.
The L-type amino acid transporter LAT1 inhibits osteoclastogenesis and maintains bone homeostasis through the mTORC1 pathway.
Ozaki K, Yamada T, Horie T, Ishizaki A, Hiraiwa M, Iezaki T, Park G, Fukasawa K, Kamada H, Tokumura K, Motono M, Kaneda K, Ogawa K, Ochi H, Sato S, Kobayashi Y, Shi YB, Taylor PM, Hinoi E. Ozaki K, et al. Among authors: tokumura k. Sci Signal. 2019 Jul 9;12(589):eaaw3921. doi: 10.1126/scisignal.aaw3921. Sci Signal. 2019. PMID: 31289211 Free PMC article.
mTOR regulates skeletogenesis through canonical and noncanonical pathways.
Tokumura K, Iwahashi S, Park G, Ochiai S, Okayama Y, Fusawa H, Fukasawa K, Iezaki T, Hinoi E. Tokumura K, et al. Biochem Biophys Res Commun. 2020 Nov 26;533(1):30-35. doi: 10.1016/j.bbrc.2020.09.002. Epub 2020 Sep 8. Biochem Biophys Res Commun. 2020. PMID: 32917361
mTORC1 Overactivation Leads to Abnormalities in Skeletal Development.
Iwahashi S, Tokumura K, Park G, Ochiai S, Okayama Y, Fusawa H, Ohta K, Fukasawa K, Iezaki T, Hinoi E. Iwahashi S, et al. Among authors: tokumura k. Biol Pharm Bull. 2020;43(12):1983-1986. doi: 10.1248/bpb.b20-00619. Biol Pharm Bull. 2020. PMID: 33268720 Free article.
CDK8 maintains stemness and tumorigenicity of glioma stem cells by regulating the c-MYC pathway.
Fukasawa K, Kadota T, Horie T, Tokumura K, Terada R, Kitaguchi Y, Park G, Ochiai S, Iwahashi S, Okayama Y, Hiraiwa M, Yamada T, Iezaki T, Kaneda K, Yamamoto M, Kitao T, Shirahase H, Hazawa M, Wong RW, Todo T, Hirao A, Hinoi E. Fukasawa K, et al. Among authors: tokumura k. Oncogene. 2021 Apr;40(15):2803-2815. doi: 10.1038/s41388-021-01745-1. Epub 2021 Mar 16. Oncogene. 2021. PMID: 33727660
22 results