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Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2.
Pymm P, Redmond SJ, Dolezal O, Mordant F, Lopez E, Cooney JP, Davidson KC, Haycroft ER, Tan CW, Seneviratna R, Grimley SL, Purcell DFJ, Kent SJ, Wheatley AK, Wang LF, Leis A, Glukhova A, Pellegrini M, Chung AW, Subbarao K, Uldrich AP, Tham WH, Godfrey DI, Gherardin NA. Pymm P, et al. Among authors: cooney jp. iScience. 2022 Nov 18;25(11):105259. doi: 10.1016/j.isci.2022.105259. Epub 2022 Oct 4. iScience. 2022. PMID: 36213007 Free PMC article.
Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.
Klemm T, Ebert G, Calleja DJ, Allison CC, Richardson LW, Bernardini JP, Lu BG, Kuchel NW, Grohmann C, Shibata Y, Gan ZY, Cooney JP, Doerflinger M, Au AE, Blackmore TR, van der Heden van Noort GJ, Geurink PP, Ovaa H, Newman J, Riboldi-Tunnicliffe A, Czabotar PE, Mitchell JP, Feltham R, Lechtenberg BC, Lowes KN, Dewson G, Pellegrini M, Lessene G, Komander D. Klemm T, et al. Among authors: cooney jp. EMBO J. 2020 Sep 15;39(18):e106275. doi: 10.15252/embj.2020106275. Epub 2020 Aug 26. EMBO J. 2020. PMID: 32845033 Free PMC article.
Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice.
Pymm P, Adair A, Chan LJ, Cooney JP, Mordant FL, Allison CC, Lopez E, Haycroft ER, O'Neill MT, Tan LL, Dietrich MH, Drew D, Doerflinger M, Dengler MA, Scott NE, Wheatley AK, Gherardin NA, Venugopal H, Cromer D, Davenport MP, Pickering R, Godfrey DI, Purcell DFJ, Kent SJ, Chung AW, Subbarao K, Pellegrini M, Glukhova A, Tham WH. Pymm P, et al. Among authors: cooney jp. Proc Natl Acad Sci U S A. 2021 May 11;118(19):e2101918118. doi: 10.1073/pnas.2101918118. Proc Natl Acad Sci U S A. 2021. PMID: 33893175 Free PMC article.
Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Wheatley AK, Pymm P, Esterbauer R, Dietrich MH, Lee WS, Drew D, Kelly HG, Chan LJ, Mordant FL, Black KA, Adair A, Tan HX, Juno JA, Wragg KM, Amarasena T, Lopez E, Selva KJ, Haycroft ER, Cooney JP, Venugopal H, Tan LL, O Neill MT, Allison CC, Cromer D, Davenport MP, Bowen RA, Chung AW, Pellegrini M, Liddament MT, Glukhova A, Subbarao K, Kent SJ, Tham WH. Wheatley AK, et al. Among authors: cooney jp. Cell Rep. 2021 Oct 12;37(2):109822. doi: 10.1016/j.celrep.2021.109822. Epub 2021 Sep 25. Cell Rep. 2021. PMID: 34610292 Free PMC article.
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway.
Simpson DS, Pang J, Weir A, Kong IY, Fritsch M, Rashidi M, Cooney JP, Davidson KC, Speir M, Djajawi TM, Hughes S, Mackiewicz L, Dayton M, Anderton H, Doerflinger M, Deng Y, Huang AS, Conos SA, Tye H, Chow SH, Rahman A, Norton RS, Naderer T, Nicholson SE, Burgio G, Man SM, Groom JR, Herold MJ, Hawkins ED, Lawlor KE, Strasser A, Silke J, Pellegrini M, Kashkar H, Feltham R, Vince JE. Simpson DS, et al. Among authors: cooney jp. Immunity. 2022 Mar 8;55(3):423-441.e9. doi: 10.1016/j.immuni.2022.01.003. Epub 2022 Feb 8. Immunity. 2022. PMID: 35139355 Free PMC article.
Programmed cell death: the pathways to severe COVID-19?
Bader SM, Cooney JP, Pellegrini M, Doerflinger M. Bader SM, et al. Among authors: cooney jp. Biochem J. 2022 Mar 18;479(5):609-628. doi: 10.1042/BCJ20210602. Biochem J. 2022. PMID: 35244141 Free PMC article. Review.
Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors.
Calleja DJ, Kuchel N, Lu BGC, Birkinshaw RW, Klemm T, Doerflinger M, Cooney JP, Mackiewicz L, Au AE, Yap YQ, Blackmore TR, Katneni K, Crighton E, Newman J, Jarman KE, Call MJ, Lechtenberg BC, Czabotar PE, Pellegrini M, Charman SA, Lowes KN, Mitchell JP, Nachbur U, Lessene G, Komander D. Calleja DJ, et al. Among authors: cooney jp. Front Chem. 2022 Apr 12;10:861209. doi: 10.3389/fchem.2022.861209. eCollection 2022. Front Chem. 2022. PMID: 35494659 Free PMC article.
Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2.
Wines BD, Kurtovic L, Trist HM, Esparon S, Lopez E, Chappin K, Chan LJ, Mordant FL, Lee WS, Gherardin NA, Patel SK, Hartley GE, Pymm P, Cooney JP, Beeson JG, Godfrey DI, Burrell LM, van Zelm MC, Wheatley AK, Chung AW, Tham WH, Subbarao K, Kent SJ, Hogarth PM. Wines BD, et al. Among authors: cooney jp. Front Immunol. 2022 Jul 28;13:889372. doi: 10.3389/fimmu.2022.889372. eCollection 2022. Front Immunol. 2022. PMID: 35967361 Free PMC article.
73 results