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Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infection.
de Almeida L, da Silva ALN, Rodrigues TS, Oliveira S, Ishimoto AY, Seribelli AA, Becerra A, Andrade WA, Ataide MA, Caetano CCS, de Sá KSG, Pelisson N, Martins RB, de Paula Souza J, Arruda E, Batah SS, Castro R, Frantz FG, Cunha FQ, Cunha TM, Fabro AT, Cunha LD, Louzada-Junior P, de Oliveira RDR, Zamboni DS. de Almeida L, et al. Among authors: cunha ld, cunha tm, cunha fq. Sci Adv. 2022 Sep 16;8(37):eabo5400. doi: 10.1126/sciadv.abo5400. Epub 2022 Sep 14. Sci Adv. 2022. PMID: 36103544 Free PMC article.
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Cunha LD. Cunha LD. Cell Host Microbe. 2021 Aug 11;29(8):1216-1217. doi: 10.1016/j.chom.2021.07.010. Cell Host Microbe. 2021. PMID: 34384524 Free article.
Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells.
Salina ACG, Dos-Santos D, Rodrigues TS, Fortes-Rocha M, Freitas-Filho EG, Alzamora-Terrel DL, Castro IMS, Fraga da Silva TFC, de Lima MHF, Nascimento DC, Silva CM, Toller-Kawahisa JE, Becerra A, Oliveira S, Caetité DB, Almeida L, Ishimoto AY, Lima TM, Martins RB, Veras F, do Amaral NB, Giannini MC, Bonjorno LP, Lopes MIF, Benatti MN, Batah SS, Santana RC, Vilar FC, Martins MA, Assad RL, de Almeida SCL, de Oliveira FR, Arruda Neto E, Cunha TM, Alves-Filho JC, Bonato VLD, Cunha FQ, Fabro AT, Nakaya HI, Zamboni DS, Louzada-Junior P, Oliveira RDR, Cunha LD. Salina ACG, et al. Among authors: cunha ld, cunha tm, cunha fq. Elife. 2022 Jun 6;11:e74443. doi: 10.7554/eLife.74443. Elife. 2022. PMID: 35666101 Free PMC article.
CASP4/11 Contributes to NLRP3 Activation and COVID-19 Exacerbation.
Rodrigues TS, Caetano CCS, de Sá KSG, Almeida L, Becerra A, Gonçalves AV, Lopes LS, Oliveira S, Mascarenhas DPA, Batah SS, Silva BM, Gomes GF, Castro R, Martins RB, Avila J, Frantz FG, Cunha TM, Arruda E, Cunha FQ, Nakaya H, Cunha LD, Fabro AT, Louzada-Junior P, de Oliveira RDR, Zamboni DS. Rodrigues TS, et al. Among authors: cunha ld. J Infect Dis. 2023 Jun 15;227(12):1364-1375. doi: 10.1093/infdis/jiad037. J Infect Dis. 2023. PMID: 36763010
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients.
Rodrigues TS, de Sá KSG, Ishimoto AY, Becerra A, Oliveira S, Almeida L, Gonçalves AV, Perucello DB, Andrade WA, Castro R, Veras FP, Toller-Kawahisa JE, Nascimento DC, de Lima MHF, Silva CMS, Caetite DB, Martins RB, Castro IA, Pontelli MC, de Barros FC, do Amaral NB, Giannini MC, Bonjorno LP, Lopes MIF, Santana RC, Vilar FC, Auxiliadora-Martins M, Luppino-Assad R, de Almeida SCL, de Oliveira FR, Batah SS, Siyuan L, Benatti MN, Cunha TM, Alves-Filho JC, Cunha FQ, Cunha LD, Frantz FG, Kohlsdorf T, Fabro AT, Arruda E, de Oliveira RDR, Louzada-Junior P, Zamboni DS. Rodrigues TS, et al. Among authors: cunha ld, cunha tm, cunha fq. J Exp Med. 2021 Mar 1;218(3):e20201707. doi: 10.1084/jem.20201707. J Exp Med. 2021. PMID: 33231615 Free PMC article.
MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response.
Sônego F, Castanheira FV, Czaikoski PG, Kanashiro A, Souto FO, França RO, Nascimento DC, Freitas A, Spiller F, Cunha LD, Zamboni DS, Alves-Filho JC, Cunha FQ. Sônego F, et al. Among authors: cunha ld, cunha fq. PLoS One. 2014 Aug 1;9(8):e103734. doi: 10.1371/journal.pone.0103734. eCollection 2014. PLoS One. 2014. PMID: 25084278 Free PMC article.
52 results