Cai W - Search Results

1

Stabilized COre gene and Pathway Election uncovers pan-cancer shared pathways and a cancer-specific driver.

Kossinna P, Cai W, Lu X, Shemanko CS, Zhang Q. Kossinna P, et al. Among authors: cai w. Sci Adv. 2022 Dec 21;8(51):eabo2846. doi: 10.1126/sciadv.abo2846. Epub 2022 Dec 21. Sci Adv. 2022. PMID: 36542714 Free PMC article.

2

A Genome-Wide Screen Identifies PDPK1 as a Target to Enhance the Efficacy of MEK1/2 Inhibitors in NRAS Mutant Melanoma.

Cai W, Nguyen MQ, Wilski NA, Purwin TJ, Vernon M, Tiago M, Aplin AE. Cai W, et al. Cancer Res. 2022 Jul 18;82(14):2625-2639. doi: 10.1158/0008-5472.CAN-21-3217. Cancer Res. 2022. PMID: 35657206 Free PMC article.

3

Raptinal Induces Gasdermin E-Dependent Pyroptosis in Naïve and Therapy-Resistant Melanoma.

Vernon M, Wilski NA, Kotas D, Cai W, Pomante D, Tiago M, Alnemri ES, Aplin AE. Vernon M, et al. Among authors: cai w. Mol Cancer Res. 2022 Dec 2;20(12):1811-1821. doi: 10.1158/1541-7786.MCR-22-0040. Mol Cancer Res. 2022. PMID: 36044013 Free PMC article.

4

PBRM1 suppresses tumor growth as a novel p53 acetylation reader.

Cai W, Su L, Yang H. Cai W, et al. Mol Cell Oncol. 2020 Mar 11;7(3):1729680. doi: 10.1080/23723556.2020.1729680. eCollection 2020. Mol Cell Oncol. 2020. PMID: 32391422 Free PMC article.

5

The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions.

Cai W, Yang H. Cai W, et al. Cell Div. 2016 May 23;11:7. doi: 10.1186/s13008-016-0020-7. eCollection 2016. Cell Div. 2016. PMID: 27222660 Free PMC article. Review.

6

Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis.

Erkes DA, Cai W, Sanchez IM, Purwin TJ, Rogers C, Field CO, Berger AC, Hartsough EJ, Rodeck U, Alnemri ES, Aplin AE. Erkes DA, et al. Among authors: cai w. Cancer Discov. 2020 Feb;10(2):254-269. doi: 10.1158/2159-8290.CD-19-0672. Epub 2019 Dec 3. Cancer Discov. 2020. PMID: 31796433 Free PMC article.

7

Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma.

Capparelli C, Purwin TJ, Glasheen M, Caksa S, Tiago M, Wilski N, Pomante D, Rosenbaum S, Nguyen MQ, Cai W, Franco-Barraza J, Zheng R, Kumar G, Chervoneva I, Shimada A, Rebecca VW, Snook AE, Hookim K, Xu X, Cukierman E, Herlyn M, Aplin AE. Capparelli C, et al. Among authors: cai w. Nat Commun. 2022 Mar 16;13(1):1381. doi: 10.1038/s41467-022-28801-y. Nat Commun. 2022. PMID: 35296667 Free PMC article.

8

PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth.

Cai W, Su L, Liao L, Liu ZZ, Langbein L, Dulaimi E, Testa JR, Uzzo RG, Zhong Z, Jiang W, Yan Q, Zhang Q, Yang H. Cai W, et al. Nat Commun. 2019 Dec 20;10(1):5800. doi: 10.1038/s41467-019-13608-1. Nat Commun. 2019. PMID: 31863007 Free PMC article.

9

Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer.

Liao L, Liu ZZ, Langbein L, Cai W, Cho EA, Na J, Niu X, Jiang W, Zhong Z, Cai WL, Jagannathan G, Dulaimi E, Testa JR, Uzzo RG, Wang Y, Stark GR, Sun J, Peiper S, Xu Y, Yan Q, Yang H. Liao L, et al. Among authors: cai w, cai wl. Elife. 2018 Oct 25;7:e37925. doi: 10.7554/eLife.37925. Elife. 2018. PMID: 30355451 Free PMC article.

10

High affinity binding of H3K14ac through collaboration of bromodomains 2, 4 and 5 is critical for the molecular and tumor suppressor functions of PBRM1.

Liao L, Alicea-Velázquez NL, Langbein L, Niu X, Cai W, Cho EA, Zhang M, Greer CB, Yan Q, Cosgrove MS, Yang H. Liao L, et al. Among authors: cai w. Mol Oncol. 2019 Apr;13(4):811-828. doi: 10.1002/1878-0261.12434. Epub 2019 Feb 2. Mol Oncol. 2019. PMID: 30585695 Free PMC article.

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