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HMGA1 induces FGF19 to drive pancreatic carcinogenesis and stroma formation.
Chia L, Wang B, Kim JH, Luo LZ, Shuai S, Herrera I, Chen SY, Li L, Xian L, Huso T, Heydarian M, Reddy K, Sung WJ, Ishiyama S, Guo G, Jaffee E, Zheng L, Cope LM, Gabrielson K, Wood L, Resar L. Chia L, et al. Among authors: xian l. J Clin Invest. 2023 Mar 15;133(6):e151601. doi: 10.1172/JCI151601. J Clin Invest. 2023. PMID: 36919699 Free PMC article.
The High Mobility Group A1 (HMGA1) gene is highly overexpressed in human uterine serous carcinomas and carcinosarcomas and drives Matrix Metalloproteinase-2 (MMP-2) in a subset of tumors.
Hillion J, Roy S, Heydarian M, Cope L, Xian L, Koo M, Luo LZ, Kellyn K, Ronnett BM, Huso T, Armstrong D, Reddy K, Huso DL, Resar LMS. Hillion J, et al. Among authors: xian l. Gynecol Oncol. 2016 Jun;141(3):580-587. doi: 10.1016/j.ygyno.2016.03.020. Epub 2016 Apr 8. Gynecol Oncol. 2016. PMID: 27001612 Free PMC article.
The High Mobility Group A1 (HMGA1) Transcriptome in Cancer and Development.
Sumter TF, Xian L, Huso T, Koo M, Chang YT, Almasri TN, Chia L, Inglis C, Reid D, Resar LM. Sumter TF, et al. Among authors: xian l. Curr Mol Med. 2016;16(4):353-93. doi: 10.2174/1566524016666160316152147. Curr Mol Med. 2016. PMID: 26980699 Free PMC article. Review.
318 results