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High-throughput in situ perturbation of metabolite levels in the tumor micro-environment reveals favorable metabolic condition for increased fitness of infiltrated T-cells.
Valvo V, Parietti E, Deans K, Ahn SW, Park NR, Ferland B, Thompson D, Dominas C, Bhagavatula SK, Davidson S, Jonas O. Valvo V, et al. Among authors: davidson s. Front Cell Dev Biol. 2022 Dec 22;10:1032360. doi: 10.3389/fcell.2022.1032360. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36619865 Free PMC article.
Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors.
Davidson SM, Jonas O, Keibler MA, Hou HW, Luengo A, Mayers JR, Wyckoff J, Del Rosario AM, Whitman M, Chin CR, Condon KJ, Lammers A, Kellersberger KA, Stall BK, Stephanopoulos G, Bar-Sagi D, Han J, Rabinowitz JD, Cima MJ, Langer R, Vander Heiden MG. Davidson SM, et al. Nat Med. 2017 Feb;23(2):235-241. doi: 10.1038/nm.4256. Epub 2016 Dec 26. Nat Med. 2017. PMID: 28024083 Free PMC article.
Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival.
Yang Y, Gomez M, Marsh T, Poillet-Perez L, Sawant A, Chen L, Park NR, Jackson SR, Hu Z, Alon N, Liu C, Debnath J, Guan JL, Davidson S, Verzi M, White E. Yang Y, et al. Among authors: davidson s. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2202016119. doi: 10.1073/pnas.2202016119. Epub 2022 May 10. Proc Natl Acad Sci U S A. 2022. PMID: 35537042 Free PMC article.
Slow TCA flux and ATP production in primary solid tumours but not metastases.
Bartman CR, Weilandt DR, Shen Y, Lee WD, Han Y, TeSlaa T, Jankowski CSR, Samarah L, Park NR, da Silva-Diz V, Aleksandrova M, Gultekin Y, Marishta A, Wang L, Yang L, Roichman A, Bhatt V, Lan T, Hu Z, Xing X, Lu W, Davidson S, Wühr M, Vander Heiden MG, Herranz D, Guo JY, Kang Y, Rabinowitz JD. Bartman CR, et al. Among authors: davidson s. Nature. 2023 Feb;614(7947):349-357. doi: 10.1038/s41586-022-05661-6. Epub 2023 Feb 1. Nature. 2023. PMID: 36725930 Free PMC article.
Intratumoral drug-releasing microdevices allow in situ high-throughput pharmaco phenotyping in patients with gliomas.
Peruzzi P, Dominas C, Fell G, Bernstock JD, Blitz S, Mazzetti D, Zdioruk M, Dawood HY, Triggs DV, Ahn SW, Bhagavatula SK, Davidson SM, Tatarova Z, Pannell M, Truman K, Ball A, Gold MP, Pister V, Fraenkel E, Chiocca EA, Ligon KL, Wen PY, Jonas O. Peruzzi P, et al. Among authors: davidson sm. Sci Transl Med. 2023 Sep 6;15(712):eadi0069. doi: 10.1126/scitranslmed.adi0069. Epub 2023 Sep 6. Sci Transl Med. 2023. PMID: 37672566 Free PMC article.
Developmental basis of SHH medulloblastoma heterogeneity.
Gold MP, Ong W, Masteller AM, Ghasemi DR, Galindo JA, Park NR, Huynh NC, Donde A, Pister V, Saurez RA, Vladoiu MC, Hwang GH, Eisemann T, Donovan LK, Walker AD, Benetatos J, Dufour C, Garzia L, Segal RA, Wechsler-Reya RJ, Mesirov JP, Korshunov A, Pajtler KW, Pomeroy SL, Ayrault O, Davidson SM, Cotter JA, Taylor MD, Fraenkel E. Gold MP, et al. Nat Commun. 2024 Jan 8;15(1):270. doi: 10.1038/s41467-023-44300-0. Nat Commun. 2024. PMID: 38191555 Free PMC article.
1,823 results