Chin YK - Search Results

1

Comprehensive Peptide Cyclization Examination Yields Optimized APP Scaffolds with Improved Affinity toward Mint2.

Bartling CRO, Alexopoulou F, Kuschert S, Chin YK, Jia X, Sereikaite V, Özcelik D, Jensen TM, Jain P, Nygaard MM, Harpsøe K, Gloriam DE, Mobli M, Strømgaard K. Bartling CRO, et al. Among authors: chin yk. J Med Chem. 2023 Feb 23;66(4):3045-3057. doi: 10.1021/acs.jmedchem.2c02017. Epub 2023 Feb 7. J Med Chem. 2023. PMID: 36749163

2

Rational Engineering Defines a Molecular Switch That Is Essential for Activity of Spider-Venom Peptides against the Analgesics Target NaV1.7.

Klint JK, Chin YK, Mobli M. Klint JK, et al. Among authors: chin yk. Mol Pharmacol. 2015 Dec;88(6):1002-10. doi: 10.1124/mol.115.100784. Epub 2015 Oct 1. Mol Pharmacol. 2015. PMID: 26429937

3

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.

Chassagnon IR, McCarthy CA, Chin YK, Pineda SS, Keramidas A, Mobli M, Pham V, De Silva TM, Lynch JW, Widdop RE, Rash LD, King GF. Chassagnon IR, et al. Among authors: chin yk. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3750-3755. doi: 10.1073/pnas.1614728114. Epub 2017 Mar 20. Proc Natl Acad Sci U S A. 2017. PMID: 28320941 Free PMC article.

4

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Wingerd JS, Mozar CA, Ussing CA, Murali SS, Chin YK, Cristofori-Armstrong B, Durek T, Gilchrist J, Vaughan CW, Bosmans F, Adams DJ, Lewis RJ, Alewood PF, Mobli M, Christie MJ, Rash LD. Wingerd JS, et al. Among authors: chin yk. Sci Rep. 2017 Apr 20;7(1):974. doi: 10.1038/s41598-017-01129-0. Sci Rep. 2017. PMID: 28428547 Free PMC article.

5

Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides.

Herzig V, de Araujo AD, Greenwood KP, Chin YK, Windley MJ, Chong Y, Muttenthaler M, Mobli M, Audsley N, Nicholson GM, Alewood PF, King GF. Herzig V, et al. Among authors: chin yk. Biomedicines. 2018 Aug 28;6(3):90. doi: 10.3390/biomedicines6030090. Biomedicines. 2018. PMID: 30154370 Free PMC article.

6

Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities.

Chandra M, Chin YK, Mas C, Feathers JR, Paul B, Datta S, Chen KE, Jia X, Yang Z, Norwood SJ, Mohanty B, Bugarcic A, Teasdale RD, Henne WM, Mobli M, Collins BM. Chandra M, et al. Among authors: chin yk. Nat Commun. 2019 Apr 4;10(1):1528. doi: 10.1038/s41467-019-09355-y. Nat Commun. 2019. PMID: 30948714 Free PMC article.

7

A bivalent remipede toxin promotes calcium release via ryanodine receptor activation.

Maxwell MJ, Thekkedam C, Lamboley C, Chin YK, Crawford T, Smith JJ, Liu J, Jia X, Vetter I, Laver DR, Launikonis BS, Dulhunty A, Undheim EAB, Mobli M. Maxwell MJ, et al. Among authors: chin yk. Nat Commun. 2023 Feb 23;14(1):1036. doi: 10.1038/s41467-023-36579-w. Nat Commun. 2023. PMID: 36823422 Free PMC article.

8

Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation.

Jia X, Chin YK, Zhang AH, Crawford T, Zhu Y, Fletcher NL, Zhou Z, Hamilton BR, Stroet M, Thurecht KJ, Mobli M. Jia X, et al. Among authors: chin yk. Commun Chem. 2023 Mar 4;6(1):48. doi: 10.1038/s42004-023-00841-5. Commun Chem. 2023. PMID: 36871076 Free PMC article.

9

Backbone and side chain NMR assignments of Geobacillus stearothermophilus ZapA allow identification of residues that mediate the interaction of ZapA with FtsZ.

Nogueira ML, Sforça ML, Chin YK, Mobli M, Handler A, Gorbatyuk VY, Robson SA, King GF, Gueiros-Filho FJ, Zeri AC. Nogueira ML, et al. Among authors: chin yk. Biomol NMR Assign. 2015 Oct;9(2):387-91. doi: 10.1007/s12104-015-9615-1. Epub 2015 May 13. Biomol NMR Assign. 2015. PMID: 25967379

10

Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene.

Pineda SS, Chin YK, Undheim EAB, Senff S, Mobli M, Dauly C, Escoubas P, Nicholson GM, Kaas Q, Guo S, Herzig V, Mattick JS, King GF. Pineda SS, et al. Among authors: chin yk. Proc Natl Acad Sci U S A. 2020 May 26;117(21):11399-11408. doi: 10.1073/pnas.1914536117. Epub 2020 May 12. Proc Natl Acad Sci U S A. 2020. PMID: 32398368 Free PMC article.

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